Evidence map›Paper›PMID 35768510›Full record

ArticleNature2022

Mitochondrial RNA modifications shape metabolic plasticity in metastasis.

Sylvain Delaunay, Gloria Pascual, Bohai Feng, Kevin Klann, Mikaela Behm, Agnes Hotz-Wagenblatt, Karsten Richter, Karim Zaoui, Esther Herpel, Christian Münch and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 3 pooled it
22.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 3 syntheses or guidelines pooled it, 278 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Review
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  13. Article
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  15. The Role of NMedComm · 2026
    Review
  16. Article
  17. METTL1-mediated mOncogene · 2026
    Article
  18. Article
  19. Review
  20. Review

127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Sylvain DelaunayGerman Cancer Research Center - Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Gloria PascualInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0003-3810-6647
Bohai FengDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Kevin KlannInstitute of Biochemistry II, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0003-2276-8128
Mikaela BehmGerman Cancer Research Center - Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Agnes Hotz-WagenblattGerman Cancer Research Center - Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1523-2093
Karsten RichterGerman Cancer Research Center - Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Karim ZaouiDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Esther HerpelInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Christian MünchInstitute of Biochemistry II, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0003-3832-090X
Sabine DietmannWashington University School of Medicine in St. Louis, St. Louis, MO, USA.
Jochen HessGerman Cancer Research Center - Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Salvador Aznar BenitahInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0002-9059-5049
Michaela FryeGerman Cancer Research Center - Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. M.Frye@dkfz.de.ORCID http://orcid.org/0000-0002-5636-6840
German Cancer Research Center · DEHeidelberg University · DEGoethe University Frankfurt · DEInstitució Catalana de Recerca i Estudis Avançats · ESInstitute for Research in Biomedicine · ESWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aggressive and metastatic cancers show enhanced metabolic plasticity

Indexed as

5-MethylcytosineGlycolysisMitochondriaNeoplasm MetastasisOxidative PhosphorylationRNA, MitochondrialCD36 AntigensCell SurvivalCytosineDisease ProgressionHumansMethylationMethyltransferasesMouth NeoplasmsProtein BiosynthesisRNA, Transfer, Met5-formylcytosine5-MethylcytosineCD36 AntigensCytosineMethyltransferasesNSUN3 protein, humanRNA, MitochondrialRNA, Transfer, Met

Identifiers

PMID35768510
PMCPMC9300468
OpenAlexW4283744632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.