Evidence map›Paper›PMID 35768507›Full record

ArticleNature2022

A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.

Peiqiang Feng, Xudong Wu, Satchal K Erramilli, Joao A Paulo, Pawel Knejski, Steven P Gygi, Anthony A Kossiakoff, Tom A Rapoport

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. Polyunsaturated fatty acid metabolism in the retinal pigment epithelium and its association with outer retinal disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. "Design principles of a membrane-spanning ubiquitin ligase".bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Peroxisome Dysfunction and Steatotic Liver Disease.International journal of molecular sciences · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Chaperone-assisted cryo-EM structure ofbioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Peiqiang FengDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. peiqiang_feng@hms.harvard.edu.ORCID http://orcid.org/0000-0003-1371-0290
Xudong WuDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6492-2202
Satchal K ErramilliDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8694-7681
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4291-413X
Pawel KnejskiDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7626-0034
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3174-9359
Tom A RapoportDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. tom_rapoport@hms.harvard.edu.ORCID http://orcid.org/0000-0001-9911-4216
Howard Hughes Medical Institute · USUniversity of Chicago · USHarvard University · US

Funding

PROTEIN TRANSPORT INTO MAMMALIAN ENDOPLASMIC RETICULUMR01GM052586 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Tom A Rapoport · 1995 to 2026
$11.9M
New Sample Multiplexing Technologies to Identify Chemical Probes and Illuminate Ubiquitin BiologyR01GM067945 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GYGI, STEVEN P · 2003 to 2024
$10.5M
Chaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM052586NIGMS NIH HHS R01 GM067945NIGMS NIH HHS R01 GM117372NIGMS NIH HHS R01 GM132129
6 · The paper itself

Abstract

Peroxisomes are ubiquitous organelles that house various metabolic reactions and are essential for human health

Indexed as

Cryoelectron MicroscopyPeroxisomesUbiquitin-Protein Ligase ComplexesCytosolHumansMembrane ProteinsPeroxinsPeroxisomal Biogenesis Factor 2PolyubiquitinProtein TransportReceptors, Cytoplasmic and NuclearRING Finger DomainsMembrane ProteinsPeroxinsPeroxisomal Biogenesis Factor 2PEX10 protein, humanPEX12 protein, humanPEX2 protein, humanPolyubiquitinReceptors, Cytoplasmic and NuclearUbiquitin-Protein Ligase Complexes

Identifiers

PMID35768507
PMCPMC9279156
OpenAlexW4283746104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.