ArticleNature2022
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers.
0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed
33.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
193 citing papers in PubMed, 306 citations in OpenAlex.
- Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling.Synthetic and systems biotechnology · 2027Article
- Genomic, epigenomic and transcriptomic regulation of cellular senescence.Nature reviews. Genetics · 2026Review
- Hippo-YAP/TAZ signalling at the crossroads of brain ageing and neurological disorders: mechanisms, crosstalk, and therapeutic prospects.Biogerontology · 2026Review
- Vascular aging as a driver of organ dysfunction and systemic aging.Nature cardiovascular research · 2026Review
- Flexible high-resolution ECM micropatterning.Nature protocols · 2026Review
- ADAMTS14 is a novel modulator of fibroblast mechanoactivation in pulmonary fibrosis.American journal of respiratory and critical care medicine · 2026Article
- Bone aging: a paradigm of multiscale degeneration and targeted rejuvenation.Bone research · 2026Review
- The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026Review
- Chromatin condensates tune nuclear mechanosensing and preserve nuclear integrity to prevent cGAS activation.The EMBO journal · 2026Article
- Noncircadian BMAL1-YAP activity amplifies persistent inflammation in aged epidermis.Nature aging · 2026Article
- Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Hardened ground: ECM stiffness as a unifying biomechanical driver of reproductive stem cell aging.Biogerontology · 2026Review
- Review
- Simulated Microgravity Induced Mesenchymal Stem Cell Senescence via the Activation of Cytosolic mtDNA-cGAS-STING Axis.Journal of cellular physiology · 2026Article
- Article
- [Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.Cell death and differentiation · 2026Article
- From ECM Aging to Mechanobiological Restoration: Injectable Fillers and Dermal Fibroblast Mechanotransduction-A Narrative Review.Gels (Basel, Switzerland) · 2026Review
- LATS1/2-CD38 Metabolic Rewiring Links Senescence to Intraplaque Thrombosis.Circulation research · 2026Article
- Positive TAZ-TDG feedback loop drives proneural-to-mesenchymal transition to promote glioblastoma progression.Journal of translational medicine · 2026Article
133 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 4 institutions in 1 country.
Hanna Lucie Sladitschek-Martens *Department of Molecular Medicine, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0001-8910-1999
Alberto Guarnieri *Department of Molecular Medicine, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0003-4546-0775
Giulia BrumanaDepartment of Molecular Medicine, University of Padua, Padua, Italy.
Francesca ZanconatoDepartment of Molecular Medicine, University of Padua, Padua, Italy.
Giusy BattilanaDepartment of Molecular Medicine, University of Padua, Padua, Italy.
Romy Lucon XiccatoDepartment of Molecular Medicine, University of Padua, Padua, Italy.
Tito PancieraDepartment of Molecular Medicine, University of Padua, Padua, Italy.
Mattia ForcatoDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID http://orcid.org/0000-0002-7383-6576
Silvio BicciatoDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID http://orcid.org/0000-0002-1944-7078
Vincenza GuzzardoDepartment of Medicine, University of Padua, Padua, Italy.
Matteo FassanDepartment of Medicine, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0001-6515-5482
Lorenzo UllianaDepartment of Industrial Engineering, University of Padua, Padua, Italy.
Alessandro GandinDepartment of Industrial Engineering, University of Padua, Padua, Italy.
Claudio TripodoDepartment of Health Sciences Unit, Human Pathology Section, University of Palermo, Palermo, Italy.
Marco FoianiIFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy.ORCID http://orcid.org/0000-0003-4795-834X
Giovanna BrusatinDepartment of Industrial Engineering, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0002-5219-8376
Michelangelo CordenonsiDepartment of Molecular Medicine, University of Padua, Padua, Italy.ORCID http://orcid.org/0000-0002-8253-5724
Stefano PiccoloDepartment of Molecular Medicine, University of Padua, Padua, Italy. piccolo@bio.unipd.it.ORCID http://orcid.org/0000-0002-1600-3092
University of Padua · ITUniversity of Modena and Reggio Emilia · ITIFOM · ITUniversity of Milan · IT
Funding
European Research Council 670126
Abstract
Ageing is intimately connected to the induction of cell senescence
Indexed as
AgingMembrane ProteinsNucleotidyltransferasesStromal CellsTranscriptional Coactivator with PDZ-Binding Motif ProteinsYAP-Signaling ProteinsActin-Related Protein 2Cellular SenescenceExtracellular MatrixHealthy AgingImmunity, InnateLamin Type BMechanotransduction, CellularNuclear EnvelopeSignal TransductionActin-Related Protein 2Lamin Type BMembrane ProteinsNucleotidyltransferasesTranscriptional Coactivator with PDZ-Binding Motif ProteinsYAP-Signaling Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.