SynthesisNature communications2022
The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness.
Synthesis in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness.Nature communications · 2022Pooled it
- Integrating genome-wide association studies with quantitative trait loci prioritisedERJ open research · 2026Article
- Association of the LncRNA TINCR rs2288947 polymorphism with survival outcomes in severe pneumonia among Han Chinese children.European journal of medical research · 2026Article
- Mendelian randomization analysis of 1,400 genetically predicted blood metabolites and ovarian cancer risk.Archives of medical science : AMS · 2026Article
- Drug repurposing candidates for amyotrophic lateral sclerosis using common and rare genetic variants.Brain communications · 2025Article
- An Efficient Dual-Sampling Approach for Chest CT Diagnosis.Journal of multidisciplinary healthcare · 2025Article
- A genome-wide association study of adults with community-acquired pneumonia.Respiratory research · 2024Article
- Structural and genetic diversity in the secreted mucins MUC5AC and MUC5B.American journal of human genetics · 2024Article
- Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension.Circulation · 2024Observational
- Structural and genetic diversity in the secreted mucins,bioRxiv : the preprint server for biology · 2024Article
- Genetic influences on circulating retinol and its relationship to human health.Nature communications · 2024Article
- Genomic regions and biological pathways associated with sex-limited reproductive traits in bovine species.Journal of animal science · 2024Article
- Altered IL-6 signalling and risk of tuberculosis disease: a meta-analysis and Mendelian randomisation study.medRxiv : the preprint server for health sciences · 2023Article
- Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder.American journal of human genetics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Pneumonia remains one of the leading causes of death worldwide. In this study, we use genome-wide meta-analysis of lifetime pneumonia diagnosis (N = 391,044) to identify four association signals outside of the previously implicated major histocompatibility complex region. Integrative analyses and finemapping of these signals support clinically tractable targets, including the mucin MUC5AC and tumour necrosis factor receptor superfamily member TNFRSF1A. Moreover, we demonstrate widespread evidence of genetic overlap with pneumonia susceptibility across the human phenome, including particularly significant correlations with psychiatric phenotypes that remain significant after testing differing phenotype definitions for pneumonia or genetically conditioning on smoking behaviour. Finally, we show how polygenic risk could be utilised for precision treatment formulation or drug repurposing through pneumonia risk scores constructed using variants mapped to pathways with known drug targets. In summary, we provide insights into the genetic architecture of pneumonia susceptibility and genetics informed targets for drug development or repositioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.