Evidence map›Paper›PMID 35768447›Full record

ArticleScientific reports2022

Evaluating utility and feasibility of mismatch repair testing of colorectal cancer patients in a low-middle-income country.

Inas Elsayed, Robert Geraghty, Salwa O Mekki, Ahmed A Mohamedani, Susan Ahern, Omer E H Salim, Balgis B M Khalil, Sawsan Abdelrahim, Suliman H Suliman, Moawia M A Elhassan and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Inas ElsayedBiomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Robert GeraghtyDepartment of Pathology, Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin 4, Ireland.
Salwa O MekkiDepartment of Histopathology, Soba University Hospital, Khartoum, Sudan.
Ahmed A MohamedaniDepartment of Pathology, Faculty of Medicine, University of Gezira, P.O. Box: 20, Wad Madani, Sudan.
Susan AhernDepartment of Pathology, Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin 4, Ireland.
Omer E H SalimDepartment of Surgery, Soba University Hospital, Khartoum, Sudan.
Balgis B M KhalilDepartment of Histopathology, Ibn Sina Specialized Hospital, Khartoum, Sudan.
Sawsan AbdelrahimDepartment of Histopathology, Soba University Hospital, Khartoum, Sudan.
Suliman H SulimanDepartment of Surgery, Soba University Hospital, Khartoum, Sudan.
Moawia M A ElhassanDepartment of Oncology, National Cancer Institute, University of Gezira, P.O. Box: 20, Wad Madani, Sudan.
Salah O SalahDepartment of Oncology, Khartoum Oncology Hospital, Khartoum, Sudan.
Mohamed E SalihDepartment of Surgery, Faculty of Medicine, University of Gezira, P.O. Box: 20, Wad Madani, Sudan.
Abubakr H WidatallaDepartment of Surgery, Soba University Hospital, Khartoum, Sudan.
Osman S AbdelhamedDepartment of Surgery, Soba University Hospital, Khartoum, Sudan.
Xiaosheng WangBiomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Éanna J RyanDepartment of Surgery, Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin, Ireland.
Des WinterDepartment of Surgery, Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin, Ireland.
Salih BakhietHull Royal Infirmary, Hull University Hospital NHS Trust, Hull, East Yorkshire, UK.
Kieran SheahanDepartment of Pathology, Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin 4, Ireland. ksheahan@svhg.ie.
St. Vincent's University Hospital · IEUniversity of Gezira · SDChina Pharmaceutical University · CNHull Royal Infirmary · GBUniversity College Dublin · IEUniversity of Khartoum · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular pathology services for colorectal cancer (CRC) in Sudan represent a significant unmet clinical need. In a retrospective cohort study involving 50 patients diagnosed with CRC at three major medical settings in Sudan, we aimed to outline the introduction of a molecular genetic service for CRC in Sudan, and to explore the CRC molecular features and their relationship to patient survival and clinicopathological characteristics. Mismatch repair (MMR) and BRAF (V600E) mutation status were determined by immunohistochemistry. A mismatch repair deficient (dMMR) subtype was demonstrated in 16% of cases, and a presumptive Lynch Syndrome (LS) diagnosis was made in up to 14% of patients. dMMR CRC in Sudan is characterized by younger age at diagnosis and a higher incidence of right-sided tumours. We report a high mortality in Sudanese CRC patients, which correlates with advanced disease stage, and MMR status. Routine MMR immunohistochemistry (with sequential BRAF mutation analysis) is a feasible CRC prognostic and predictive molecular biomarker, as well as a screening tool for LS in low-middle-income countries (LMICs).

Indexed as

Colorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisDNA Mismatch RepairFeasibility StudiesHumansMicrosatellite InstabilityProto-Oncogene Proteins B-rafRetrospective StudiesProto-Oncogene Proteins B-raf

Identifiers

PMID35768447
PMCPMC9243080
OpenAlexW4283765405

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.