Evidence map›Paper›PMID 35768409›Full record

ArticleNature communications2022

A guided multiverse study of neuroimaging analyses.

Jessica Dafflon, Pedro F Da Costa, František Váša, Ricardo Pio Monti, Danilo Bzdok, Peter J Hellyer, Federico Turkheimer, Jonathan Smallwood, Emily Jones, Robert Leech

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  4. Review
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  12. A data-driven algorithm to determineMagnetic resonance in medicine · 2026
    Article
  13. Article
  14. Estimating the extent and sources of model uncertainty in political science.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jessica DafflonCentre for Neuroimaging Sciences, King's College London, London, UK. jessica.dafflon@gmail.com.ORCID 0000-0003-2540-0927
Pedro F Da CostaCentre for Neuroimaging Sciences, King's College London, London, UK.ORCID 0000-0003-1291-518X
František VášaCentre for Neuroimaging Sciences, King's College London, London, UK.ORCID 0000-0001-6744-7139
Ricardo Pio MontiGatsby Computational Neuroscience, University College London, London, UK.
Danilo BzdokDepartment of Biomedical Engineering, McGill University, Montreal, Canada.ORCID 0000-0003-3466-6620
Peter J HellyerCentre for Neuroimaging Sciences, King's College London, London, UK.
Federico TurkheimerCentre for Neuroimaging Sciences, King's College London, London, UK.
Jonathan SmallwoodDepartment of Psychology, Queen's University, Kingston, ON, Canada.ORCID 0000-0002-7298-2459
Emily JonesCenter for Brain and Cognitive Development, Birkbeck College, London, UK.
Robert LeechCentre for Neuroimaging Sciences, King's College London, London, UK. robertleech6@gmail.com.ORCID 0000-0002-5801-6318

Funding

Medical Research Council MR/R005370/1Wellcome TrustWellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

For most neuroimaging questions the range of possible analytic choices makes it unclear how to evaluate conclusions from any single analytic method. One possible way to address this issue is to evaluate all possible analyses using a multiverse approach, however, this can be computationally challenging and sequential analyses on the same data can compromise predictive power. Here, we establish how active learning on a low-dimensional space capturing the inter-relationships between pipelines can efficiently approximate the full spectrum of analyses. This approach balances the benefits of a multiverse analysis without incurring the cost on computational and predictive power. We illustrate this approach with two functional MRI datasets (predicting brain age and autism diagnosis) demonstrating how a multiverse of analyses can be efficiently navigated and mapped out using active learning. Furthermore, our presented approach not only identifies the subset of analysis techniques that are best able to predict age or classify individuals with autism spectrum disorder and healthy controls, but it also allows the relationships between analyses to be quantified.

Indexed as

Autism Spectrum DisorderBrainHumansMagnetic Resonance ImagingNeuroimaging

Identifiers

PMID35768409
PMCPMC9243029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.