Evidence map›Paper›PMID 35768194›Full record

ArticleJournal of medical genetics2022

Cancer risk and tumour spectrum in 172 patients with a germline

Léa Guerrini-Rousseau, Julien Masliah-Planchon, Sebastian M Waszak, Pia Alhopuro, Patrick R Benusiglio, Franck Bourdeaut, Ines B Brecht, Giada Del Baldo, Sandeep Kumar Dhanda, Maria Luisa Garrè and 18 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 12 countries.

Léa Guerrini-RousseauDepartment of Children and Adolescents Oncology, Gustave Roussy, Villejuif, France lea.guerrini-rousseau@gustaveroussy.fr.ORCID http://orcid.org/0000-0003-0050-5407
Julien Masliah-PlanchonINSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO Pediatric Oncology Center, Institute Curie, Paris, France.
Sebastian M WaszakCentre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.
Pia AlhopuroDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Patrick R BenusiglioDépartement de Génétique et Institut Universitaire de Cancérologie, Sorbonne University Faculty of Medicine Pitié-Salpêtrière Campus, Paris, France.
Franck BourdeautINSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO Pediatric Oncology Center, Institute Curie, Paris, France.
Ines B BrechtDepartment of Pediatric Oncology and Hematology, University Hospitals Tubingen, Tubingen, Germany.
Giada Del BaldoDepartment of Hematology/Oncology, Cell Therapy, Gene Therapy and Hemopoietic Transplant, IRCCS, Bambino Gesu Pediatric Hospital, Roma, Italy.
Sandeep Kumar DhandaDepartment of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID http://orcid.org/0000-0003-1381-7434
Maria Luisa GarrèNeuro-Oncology Unit, Department of Neurochirurgia, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Corrie E M GiddingNeuro-Oncology Department, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Steffen HirschInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Pauline HoarauDepartment of Children and Adolescents Oncology, Gustave Roussy, Villejuif, France.
Mette JorgensenOncology, Great Ormond Street Hospital For Children NHS Foundation Trust, London, UK.
Christian KratzPaediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany.
Lucie Lafay-CousinSection of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital and Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Angela MastronuzziPediatric Hematology/Oncology and Stem Cells Transplatation, Bambino Gesu Pediatric Hospital, Roma, Italy.
Lorenza PastorinoDepartment of Oncology, Biology and Genetics, University of Genoa, Genoa, Italy.
Stefan M PfisterHopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg Health Center, Heidelberg, Germany.
Christopher SchroederInstitute of Medical Genetics and Applied Genomics, University of Tubingen Institute of Human Genetics, Tubingen, Germany.
Miriam Jane SmithDivision of Evolution, Infection and Genomics, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-3184-0817
Pia VahteristoDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Roseline VibertDepartment of Genetics, PSL Research University, Institute Curie, Paris, France.ORCID http://orcid.org/0000-0001-5202-0212
Catheline VilainDepartment of Genetics, Hôpital Universitaire des Enfants Reine Fabiola, ULB Center of Human Genetics, Universite Libre de Bruxelles, Bruxelles, Belgium.
Nicolas WaespeCANSEARCH Research Platform, Depatment of pediatric oncology and hematology, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-2271-8959
Ingrid M WinshipDepartment of Medicine, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
D Gareth EvansManchester Centre for Genomic Medicine, St Mary's Hospital, Manchester Academic Health Science Centre, School of Biological Sciences,Division of Evolution, Infection and Genomics, The University of Manchester, Manchester, UK.
Laurence BrugieresTeam "Genomics and Oncogenesis of pediatric Brain Tumors"-Paris Saclay University, INSERM U981, VILLEJUIF, France.
Inserm · FRBambino Gesù Children's Hospital · ITHeidelberg University · DEUniversity of Helsinki · FIGreat Ormond Street Hospital for Children NHS Foundation Trust · GBInstitut Gustave Roussy · FRIstituto Giannina Gaslini · ITManchester Academic Health Science Centre · GBMedizinische Hochschule Hannover · DEOslo University Hospital · NOOspedale Policlinico San Martino · ITPrincess Máxima Center · NLSorbonne Université · FRSt. Jude Children's Research Hospital · USThe Royal Melbourne Hospital · AUUniversité Libre de Bruxelles · BEUniversité Paris Sciences et Lettres · FRUniversity Children's Hospital Tübingen · DEUniversity of Calgary · CAUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about risks associated with germline

methodsTo study tumour risks, we have analysed data of a large cohort of 45 unpublished patients with a germline

resultsOverall, 117/172 (68%)

conclusionGermline

Indexed as

central nervous system diseasescongenital, hereditary, and neonatal diseases and abnormalitiesgenetic counselinggenetic predisposition to diseasegerm-line mutation

Identifiers

PMID35768194
PMCPMC9613872
OpenAlexW4283706843

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.