ArticleCell2022
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07278206 (Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID), which is not on this map. Cited by 315 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
315citing papers in PubMed, 1 pooled it
39.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID
Who cites it
315 citing papers in PubMed, 1 synthesis or guideline pooled it, 493 citations in OpenAlex.
- Prevalence and long-term outcomes of brain fog and cognitive impairment in individuals with long COVID: A systematic review.Medicine · 2026Pooled it
- Remote ischemic conditioning improves neuropsychiatric symptoms in COVID-19 patients: a randomized clinical trial.Frontiers in psychiatry · 2025Trial
- Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026Review
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- Oligodendrocyte dysfunction in human age-related cognitive decline.Nature medicine · 2026Article
- Possible Volumetric Changes in the Hippocampus and Olfactory Bulbs After COVID-19: A Stereological MRI Study.Viruses · 2026Article
- COVID-19 Is Airborne AIDS: Provocative Oversimplification, Emerging Science, or Something in Between?AJPM focus · 2026Review
- Selective Anti-Inflammatory Actions of Curcumin on Cytokine Pathways in Major Depressive Disorder.Brain and behavior · 2026Article
- Lung endothelial cytopathic tau is sufficient to impair long-term potentiation during infection.American journal of respiratory cell and molecular biology · 2026Article
- Neurodegenerative and Cognitive Consequences of Long COVID.International journal of molecular sciences · 2026Review
- Longitudinal analysis reveals myeloid cell contributions to murine neuroPASC pathogenesis.Nature communications · 2026Article
- Zika virus infection in the brains of lymphocyte-deficient mice does not lead to neurological symptoms despite sustained high viral load.Journal of neurovirology · 2026Article
- Understanding the long-term neurological effects of SARS-CoV-2 infection.Nature reviews. Neurology · 2026Review
- Assessing Cognitive Deterioration After COVID-19 Infection (The ACDC Study): An Exploratory Multimodal Neuroimaging Study.Journal of clinical medicine · 2026Article
- Memory Impairments: Type, Causes, and Molecular Players-Memory Dysfunction Across Neurologic Insults.Cells · 2026Review
- Article
- Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice.bioRxiv : the preprint server for biology · 2026Article
- LearningRx Cognitive Training for Workplace Self-Efficacy in Adults with Post-COVID-19 Brain Fog: A Mixed-Methods Pilot Study.Brain sciences · 2026Article
- SARS-CoV-2 Effects on Respiratory and Neurological Systems: Morphological Findings and Gene Expression in K18-hACE2 Mice Model.Microorganisms · 2026Article
255 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
45 authors at 10 institutions in 1 country.
Anthony Fernández-CastañedaDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Peiwen LuDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Anna C GeraghtyDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Eric SongDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Myoung-Hwa LeeNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Jamie WoodAbilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
Michael R O'DeaNeuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA.
Selena DuttonDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Kiarash ShamardaniDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Kamsi NwangwuDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Rebecca MancusiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Belgin YalçınDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Kathryn R TaylorDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Lehi Acosta-AlvarezDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Karen MalaconDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Michael B KeoughDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Lijun NiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Pamelyn J WooDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Daniel Contreras-EsquivelDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Angus Martin Shaw TolandDepartment of Pathology, Stanford University, Stanford, CA, USA.
Jeff R GehlhausenDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Jon KleinDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Takehiro TakahashiDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Julio SilvaDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Benjamin IsraelowDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Carolina LucasDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Tianyang MaoDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Mario A Peña-HernándezDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Alexandra TabachnikovaDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Robert J HomerDepartment of Pathology, Yale University, New Haven, CT, USA.
Laura TabacofAbilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
Jenna Tosto-MancusoAbilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
Erica BreymanAbilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
Amy KontorovichCardiovascular Research Institute, Mount Sinai School of Medicine, New York, NY, USA.
Dayna McCarthyAbilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
Martha QuezadoNational Cancer Institute, Bethesda, MD, USA.
Hannes VogelDepartment of Pathology, Stanford University, Stanford, CA, USA.
Marco M HeftiDepartment of Pathology, University of Iowa, Iowa City, IA, USA.
Daniel P PerlDepartment of Pathology, Uniformed Services University of Health Sciences, Bethesda, MD, USA.
Shane LiddelowNeuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA; Departments of Neuroscience & Physiology and of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA; Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Rebecca FolkerthOffice of Chief Medical Examiner, New York, NY, USA.
David PutrinoAbilities Research Center, Department of Rehabilitation and Human Performance, Mount Sinai School of Medicine, New York, NY, USA.
Avindra NathNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Akiko IwasakiDepartment of Immunobiology, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT, USA. Electronic address: akiko.iwasaki@yale.edu.
Michelle MonjeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. Electronic address: mmonje@stanford.edu.
Stanford University · USYale University · USIcahn School of Medicine at Mount Sinai · USHoward Hughes Medical Institute · USNational Institute of Neurological Disorders and Stroke · USNational Cancer Institute · USNew York University · USOffice of Chief Medical Examiner · USUniformed Services University of the Health Sciences · USUniversity of Iowa · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MNeuropathogenesis of Retroviral InfectionsZIANS003130 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2011 to 2025
$73.7MTranslational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8MLeveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4MMedical Scientist Training ProgramT32GM145402 · NIGMS · STANFORD UNIVERSITY · PI Katrin F. Chua · 2022 to 2026
$10.0MGlioma Circuitry: Bridging Systems Neuroscience and CancerDP1NS111132 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2018 to 2022
$5.7MViral and immune-mediated CNS pathology during SARS-CoV-2 infectionR01AI157488 · NIAID · YALE UNIVERSITY · PI FARHADIAN, SHELLI, IWASAKI, AKIKO · 2020 to 2024
$4.7MNeurotoxicity of Reactive Astrocyte-secreted Lipids in Neurodegenerative DiseaseR01EY033353 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Shane Liddelow · 2022 to 2026
$2.5MNeuronal activity-regulated mechanisms of glioma growthR01NS092597 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2016 to 2021
$2.1MInnate Control of Adaptive Immunity to SARS-CoV-2K08AI163493 · NIAID · YALE UNIVERSITY · PI GOLDMAN-ISRAELOW, BENJAMIN · 2021 to 2025
$969kCancer Research UKHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA124435NCI NIH HHS T32 CA009302NEI NIH HHS R01 EY033353NIAID NIH HHS K08 AI163493NIAID NIH HHS R01 AI157488NIAID NIH HHS T32 AI007019NIGMS NIH HHS T32 GM007365NIGMS NIH HHS T32 GM145402NINDS NIH HHS DP1 NS111132NINDS NIH HHS K23 NS109284NINDS NIH HHS R01 NS092597
Abstract
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans. Following mild respiratory COVID in mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes, and myelin loss were evident together with elevated CSF cytokines/chemokines including CCL11. Systemic CCL11 administration specifically caused hippocampal microglial reactivity and impaired neurogenesis. Concordantly, humans with lasting cognitive symptoms post-COVID exhibit elevated CCL11 levels. Compared with SARS-CoV-2, mild respiratory influenza in mice caused similar patterns of white-matter-selective microglial reactivity, oligodendrocyte loss, impaired neurogenesis, and elevated CCL11 at early time points, but after influenza, only elevated CCL11 and hippocampal pathology persisted. These findings illustrate similar neuropathophysiology after cancer therapy and respiratory SARS-CoV-2 infection which may contribute to cognitive impairment following even mild COVID.
Indexed as
COVID-19Influenza, HumanNeoplasmsAnimalsHumansMiceMicrogliaMyelin SheathSARS-CoV-2cognitive impairmentCOVID-19H1N1 influenzahippocampal neurogenesislong COVIDmicrogliamyelinneuroinflammationoligodendrocytes
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Registered trials
NCT07278206ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.