Evidence map›Paper›PMID 35767977›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2022

Postdiagnostic Inflammatory, Hyperinsulinemic, and Insulin-Resistant Diets and Lifestyles and the Risk of Prostate Cancer Progression and Mortality.

Crystal S Langlais, Rebecca E Graff, Erin L Van Blarigan, Stacey A Kenfield, John Neuhaus, Fred K Tabung, Janet E Cowan, Jeanette M Broering, Peter Carroll, June M Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Crystal S LanglaisDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0001-5654-5542
Rebecca E GraffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0003-0316-8303
Erin L Van BlariganDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0001-5079-3385
Stacey A KenfieldDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-1585-7352
John NeuhausDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0003-0998-4352
Fred K TabungDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, Ohio.ORCID 0000-0001-8193-7150
Janet E CowanDepartment of Urology, University of California, San Francisco, San Francisco, California.ORCID 0000-0003-1852-8260
Jeanette M BroeringDepartment of Urology, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-7580-8931
Peter CarrollHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
June M ChanDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-7620-569X

Funding

Diet After Colorectal Cancer : Observational Studies to Behavioral InterventionsK07CA197077 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAN BLARIGAN, ERIN LYNN · 2016 to 2020
$885k
Impact of Modifiable Diet and Lifestyle Factors on Prostate Cancer ProgressionF31CA247093 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGLAIS, CRYSTAL · 2020 to 2021
$54k
NCI NIH HHS F31 CA247093NCI NIH HHS K07 CA197077
6 · The paper itself

Abstract

backgroundInflammatory and insulin pathways have been linked to prostate cancer; postdiagnostic behaviors activating these pathways may lead to poor outcomes. The empirical dietary inflammatory pattern (EDIP), empirical dietary index for hyperinsulinemia (EDIH), and empirical dietary index for insulin resistance (EDIR), and associated lifestyle indices (ELIH, ELIR) predict biomarkers of inflammation (EDIP: IL6, TNFaR2, CRP) and insulin secretion (EDIH/ELIH: c-peptide; EDIR/ELIR: TAG:HDL) from whole foods and behaviors.

methodsAssociations of these indices with time to prostate cancer progression (primary, n = 2,056) and prostate cancer-specific mortality (PCSM; secondary, n = 2,447) were estimated among men diagnosed with nonmetastatic prostate cancer in the Cancer of the Prostate Strategic Urologic Research Endeavor cohort diet and lifestyle sub-study. Because the true (versus clinically documented) date of progression is unobserved, we used parametric (Weibull) survival models to accommodate interval-censoringand estimated adjusted HR and 95% confidence intervals (CI) for prostate cancer progression per 1-SD increase in index. Cox proportional hazards models were used to estimate PCSM associations.

resultsDuring a median [interquartile range (IQR)] 6.4 years (IQR, 1.3-12.7), 192 progression and 73 PCSM events were observed. Inflammatory (EDIP: HR, 1.27; CI, 1.17-1.37), hyperinsulinemic (EDIH: HR, 1.24; CI, 1.05-1.46. ELIH: HR, 1.34; CI, 1.17-1.54), and insulin-resistant (EDIR: HR, 1.22; CI, 1.00-1.48. ELIR: HR, 1.36; CI, 1.12-1.64) indices were positively associated with risk of prostate cancer progression. There was no evidence of associations between the indices and PCSM.

conclusionsBoth inflammatory and insulinemic dietary and lifestyle patterns are associated with risk of prostate cancer progression. IMPACT: For men with prostate cancer, consuming dietary patterns that limit chronic systemic inflammation and insulin hypersecretion may improve survivorship, especially when coupled with active lifestyle and healthy body weight. See related commentary by Kucuk, p. 1673.

Indexed as

HyperinsulinismProstatic NeoplasmsDietHumansInflammationInsulinLife StyleMaleRisk FactorsInsulin

Identifiers

PMID35767977
PMCPMC9444922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.