ArticleCell reports2022
Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Spatiotemporal control of myoblast identity drives muscle diversity in theScience advances · 2026Article
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- From development to disease: the neuronal role of hnRNPs through the lens ofFrontiers in cell and developmental biology · 2026Review
- A critical affinity window for IgSF proteins DIP-α and Dpr10 is required for proper motor neuron arborization.Genes & development · 2025Article
- A unified framework for identification of cell-type-specific spatially variable genes in spatial transcriptomic studies.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Decoding neuronal diversity: Mechanisms governing neural cell fate in Drosophila.Current opinion in neurobiology · 2025Review
- Imp and Chinmo are required for embryonic motor neuron axon and dendrite targeting.Biology open · 2025Article
- Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity.bioRxiv : the preprint server for biology · 2025Article
- Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators ofScience advances · 2025Article
- Dynamic mRNA Stability Buffer Transcriptional Activation During Neuronal Differentiation and Is Regulated by SAMD4A.Journal of cellular physiology · 2025Article
- Article
- Article
- Synaptic architecture of leg and wing premotor control networks inbioRxiv : the preprint server for biology · 2024Article
- Review
- The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila.Current biology : CB · 2024Article
- The RNA-binding protein, Imp specifies olfactory navigation circuitry and behavior inbioRxiv : the preprint server for biology · 2023Article
- RNA-Binding Proteins as Epigenetic Regulators of Brain Functions and Their Involvement in Neurodegeneration.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
How the vast array of neuronal diversity is generated remains an unsolved problem. Here, we investigate how 29 morphologically distinct leg motoneurons are generated from a single stem cell in Drosophila. We identify 19 transcription factor (TF) codes expressed in immature motoneurons just before their morphological differentiation. Using genetic manipulations and a computational tool, we demonstrate that the TF codes are progressively established in immature motoneurons according to their birth order. Comparing RNA and protein expression patterns of multiple TFs reveals that post-transcriptional regulation plays an essential role in shaping these TF codes. Two RNA-binding proteins, Imp and Syp, expressed in opposing gradients in immature motoneurons, control the translation of multiple TFs. The varying sensitivity of TF mRNAs to the opposing gradients of Imp and Syp in immature motoneurons decrypts these gradients into distinct TF codes, establishing the connectome between motoneuron axons and their target muscles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.