Evidence map›Paper›PMID 35767897›Full record

ArticleBlood2022

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data.

Daniel A Arber, Attilio Orazi, Robert P Hasserjian, Michael J Borowitz, Katherine R Calvo, Hans-Michael Kvasnicka, Sa A Wang, Adam Bagg, Tiziano Barbui, Susan Branford and 58 more

3 registry-linked trialsAbstract readConsensus Statement
In one paragraph

Article in Blood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1,667 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,667citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06175702 not yet recruitingnot on this mapstarted 2023, after this paper: background citation

Treatment Protocol for Newky Diagnosed Adult Ph-Chromosome Positive (BCR::ABL1) Acute Lymphoblastic Leukemia (LALPh2022)

TypeobservationalSponsorPETHEMA FoundationRan2023 to 2030Enrolled150ConditionsLymphoblastic Leukemia, Philadelphia-Positive ALL, Adult ALLArmsVincristine, Dexamethasone, Imatinib, Cytarabine, Mercaptopurine
NCT06483906 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Venetoclax and Azacitidine Combined With Low-Intensity Homoharringtonine Chemotherapy Followed by Allogeneic Hematopoietic Stem Cell Transplantation in Intermediate/High-Risk Newly Diagnosed Acute Myeloid Leukemia

TypeinterventionalSponsorShanghai General Hospital, Shanghai Jiao Tong University School of MedicineRan2024 to 2028Enrolled56ConditionsAcute Myeloid LeukemiaArmsVenetoclax, Azacitidine and Homoharringtonine
NCT07469046 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Venetoclax, Azacitidine Combined With Homoharringtonine Versus Venetoclax and Azacitidine in Newly Diagnosed Elderly (60-75 Years) Acute Myeloid Leukemia: A Multicenter, Open-label, Randomized, Controlled Clinical Trial

TypeinterventionalSponsorShanghai General Hospital, Shanghai Jiao Tong University School of MedicineRan2026 to 2029Enrolled308ConditionsAcute Myeloid Leukemia (AML), Elderly Patients (60-75 Years)ArmsVenetoclax, Azacitidine, Homoharringtonine
3 · Its place in the literature

Who cites it

1,667 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
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  4. Feasibility and preliminary effects of mhealth supportive care interventions in adults with myeloid neoplasms: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  9. SuperRCA assay ofThe journal of allergy and clinical immunology. Global · 2026
    Article
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1,607 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

68 authors.

Daniel A ArberUniversity of Chicago, Chicago, IL.ORCID 0000-0002-2160-9689
Attilio OraziTexas Tech University Health Sciences Center El Paso, El Paso, TX.
Robert P HasserjianMassuchusetts General Hospital, Boston, MA.ORCID 0000-0002-7753-0697
Michael J BorowitzJohns Hopkins University, Baltimore, MD.
Katherine R CalvoNational Institutes of Health Clinical Center, Bethesda, MD.
Hans-Michael KvasnickaHelios Universitätsklinikum Wuppertal, Wuppertal, Germany.ORCID 0000-0002-5450-4840
Sa A WangUniversity of Texas MD Anderson Cancer Center, Houston, TX.
Adam BaggUniversity of Pennsylvania, Philadelphia, PA.
Tiziano BarbuiClinical Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy.ORCID 0000-0003-2747-6327
Susan BranfordCentre for Cancer Biology, Adelaide, SA, Australia.ORCID 0000-0002-5095-7981
Carlos E Bueso-RamosUniversity of Texas MD Anderson Cancer Center, Houston, TX.
Jorge E CortesGeorgia Cancer Center, Augusta, GA.ORCID 0000-0002-8636-1071
Paola Dal CinBrigham and Women's Hospital, Boston, MA.
Courtney D DiNardoUniversity of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0001-9003-0390
Hervé DombretUniversité Paris Cité, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris, Paris, France.
Eric J DuncavageWashington University in St Louis, St. Louis, MO.
Benjamin L EbertDana-Farber Cancer Institute, Boston, MA.ORCID 0000-0003-0197-5451
Elihu H EsteyUniversity of Washington, Seattle, WA.
Fabio FacchettiUniversity of Brescia School of Medicine, Brescia, Italy.
Kathryn FoucarUniversity of New Mexico, Albuquerque, NM.
Naseema GangatMayo Clinic, Rochester, MN.ORCID 0000-0002-9104-6172
Umberto GianelliUniversità degli Studi di Milano, Milan, Italy.ORCID 0000-0003-3304-8417
Lucy A GodleyUniversity of Chicago, Chicago, IL.
Nicola GökbugetGoethe University, Frankfurt, Germany.
Jason GotlibStanford University School of Medicine, Stanford, CA.
Eva Hellström-LindbergKarolinska Institutet, Solna, Sweden.
Gabriela S HobbsMassuchusetts General Hospital, Boston, MA.ORCID 0000-0002-0199-9333
Ronald HoffmanMount Sinai Medical Center, New York, NY.
Elias J JabbourUniversity of Texas MD Anderson Cancer Center, Houston, TX.
Jean-Jacques KiladjianUniversité Paris Cité, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris, Paris, France.
Richard A LarsonUniversity of Chicago, Chicago, IL.ORCID 0000-0001-9168-3203
Michelle M Le BeauUniversity of Chicago, Chicago, IL.
Mignon L-C LohSeattle Children's Hospital, Seattle, WA.
Bob LöwenbergErasmus Medical Center, Rotterdam, Netherlands.ORCID 0000-0001-8982-5217
Elizabeth MacintyreUniversité Paris Cité, Paris, France.ORCID 0000-0003-0520-0493
Luca MalcovatiUniversity of Pavia, Pavia, Italy.ORCID 0000-0002-1460-1611
Charles G MullighanSt. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-1871-1850
Charlotte NiemeyerUniversity of Freiburg Medical Center, Freiburg um Breisgau, Germany.ORCID 0000-0003-3856-7937
Olatoyosi M OdenikeUniversity of Chicago, Chicago, IL.
Seishi OgawaKyoto University, Kyoto, Japan.ORCID 0000-0002-7778-5374
Alberto OrfaoUniversity of Salamanca, Salamanca, Spain.
Elli PapaemmanuilMemorial Sloan-Kettering Cancer Center, New York, NY.
Francesco PassamontiUniversity of Pavia, Pavia, Italy.ORCID 0000-0001-8068-5289
Kimmo PorkkaHelsinki University Central Hospital Comprehensive Cancer Center, Helsinki, Finland.ORCID 0000-0003-4112-5902
Ching-Hon PuiSt. Jude Children's Research Hospital, Memphis, TN.
Jerald P RadichFred Hutchinson Cancer Research Center, Seattle, WA.
Andreas ReiterUniversity Hospital Mannheim, Mannheim, Germany.
Maria RozmanUniversity of Barcelona, Barcelona, Spain.
Martina RudeliusLudwig Maximilians University Munich, Munich, Germany.
Michael R SavonaVanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-3763-5504
Charles A SchifferKarmanos Cancer Institute, Detroit, MI.
Annette Schmitt-GraeffAlbert-Ludwigs-University Freiburg, Freiburg im Breisgau, Germany.ORCID 0000-0001-5082-7979
Akiko ShimamuraDana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-4683-9958
Jorge SierraHospital Santa Creu i Sant Pau, Barcelona, Spain.
Wendy A StockUniversity of Chicago, Chicago, IL.
Richard M StoneDana-Farber Cancer Institute, Boston, MA.
Martin S TallmanLurie Children's Hospital, Chicago, IL.
Jürgen ThieleUniversity of Cologne, Köln, Germany.
Hwei-Fang TienNational Taiwan University Hospital, Taipei City, Taiwan.
Alexandar TzankovMedical University Basel, Basel, Switzerland.
Alessandro M VannucchiUniversity of Florence and AOU Careggi, Florence, Italy.ORCID 0000-0001-5755-0730
Paresh VyasUniversity of Oxford, Oxford, United Kingdom.ORCID 0000-0003-3931-0914
Andrew H WeiPeter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.ORCID 0000-0002-7514-3298
Olga K WeinbergUniversity of Texas Southwestern, Dallas, TX.
Agnieszka WierzbowskaMedical University of Lodz, Lodz, Poland; and.ORCID 0000-0001-7909-457X
Mario CazzolaUniversity of Pavia, Pavia, Italy.ORCID 0000-0001-6984-8817
Hartmut DöhnerUniversity Hospital Ulm, Ulm, Germany.ORCID 0000-0003-2116-5536
Ayalew TefferiMayo Clinic, Rochester, MN.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
The Role of microRNA in Hematologic MalignanciesZIACL090025 · CLC · CLINICAL CENTER · PI CALVO, KATHERINE · 2010 to 2025
$0k
Medical Research Council G1000729Medical Research Council MC_PC_19049Medical Research Council MC_U137961146Medical Research Council MC_UU_00016/11Medical Research Council MC_UU_00029/8Medical Research Council MC_UU_12009/11Medical Research Council MR/L008963/1NCI NIH HHS P01 CA066996NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioinformaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As a continuation of this CAC-based process, the authors, a group with expertise in the clinical, pathologic, and genetic aspects of these disorders, developed the International Consensus Classification (ICC) of myeloid neoplasms and acute leukemias. Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction of new entities and refined criteria for existing diagnostic categories, based on accumulated data. The ICC is aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.

Indexed as

Hematologic NeoplasmsLeukemiaMyeloproliferative DisordersAcute DiseaseGenomicsHumansWorld Health Organization

Identifiers

PMID35767897
PMCPMC9479031

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.