Evidence map›Paper›PMID 35767671›Full record

ArticleAmerican journal of respiratory cell and molecular biology2022

The Role of Glutathione Reductase in Influenza Infection.

Kyung Sook Hong, Kassandra Pagan, William Whalen, Rebecca Harris, Jianjun Yang, Heather Stout-Delgado, Soo Jung Cho

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Kyung Sook HongDivision of Critical Care Medicine, Department of Surgery, Ewha Womans University College of Medicine, Seoul, South Korea; and.
Kassandra PaganDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.
William WhalenDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.
Rebecca HarrisDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.
Jianjun YangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.
Heather Stout-DelgadoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.
Soo Jung ChoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.ORCID 0000-0003-0759-7295
Cornell University · USEwha Womans University · KR

Funding

Impact of Heightened UPR Activation on Inflammasome Responses to Influenza and Secondary Streptococcus pneumoniae Infection in Aged LungR01AG056699 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI STOUT DELGADO, HEATHER WINONA · 2018 to 2022
$2.6M
Impact of Heightened ER Stress on NLRP3 Activation in Aged Lung during InfectionR01AG052530 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI STOUT DELGADO, HEATHER WINONA · 2017 to 2021
$2.1M
GLUT1-dependent glycolysis regulates age-susceptible lung fibrosisK08HL138285 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHO, SOO JUNG · 2017 to 2021
$829k
NHLBI NIH HHS K08 HL138285NIA NIH HHS R01 AG052530NIA NIH HHS R01 AG056699
6 · The paper itself

Abstract

Influenza infection induces lung epithelial cell injury via programmed cell death. Glutathione, a potent antioxidant, has been reported to be associated with influenza infection. We hypothesized that lung epithelial cell death during influenza infection is regulated by glutathione metabolism. Eight-week-old male and female BALB/c mice were infected with influenza (PR8: A/PR/8/34 [H1N1]) via intranasal instillation. Metabolomic analyses were performed on whole lung lysate after influenza infection. For

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza, HumanLung InjuryOrthomyxoviridae InfectionsAnimalsAntioxidantsFemaleGlutathioneGlutathione ReductaseHumansLungMaleMiceMice, Inbred BALB CRNAAntioxidantsGlutathioneGlutathione ReductaseRNAcell deathglutathione metabolisminfluenzapneumonia

Identifiers

PMID35767671
PMCPMC9753556
OpenAlexW4283763956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.