Evidence map›Paper›PMID 35767640›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Early expression of mature αβ TCR in CD4

Kimberly G Laffey, Robert J Stiles, Melissa J Ludescher, Tessa R Davis, Shariq S Khwaja, Richard J Bram, Peter J Wettstein, Venkataraman Ramachandran, Christopher A Parks, Edwin E Reyes and 6 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Notch2-expressing CD4Cellular & molecular immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Kimberly G LaffeyDepartment of Molecular Microbiology & Immunology, School of Medicine, University of Missouri-Columbia, Columbia, MO 65212.ORCID 0000-0001-7322-9875
Robert J StilesDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.ORCID 0000-0001-8794-0019
Melissa J LudescherDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.
Tessa R DavisDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.ORCID 0000-0003-0660-7850
Shariq S KhwajaDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.
Richard J BramDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.
Peter J WettsteinDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.
Venkataraman RamachandranDepartment of Surgery, School of Medicine, University of Missouri-Columbia, Columbia, MO 65212.ORCID 0000-0001-8386-7918
Christopher A ParksDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.
Edwin E ReyesDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.
Alejandro FerrerDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55095.
Jenna M CanfieldDepartment of Molecular Microbiology & Immunology, School of Medicine, University of Missouri-Columbia, Columbia, MO 65212.ORCID 0000-0001-5980-7392
Cory E JohnsonClinical Flow Cytometry Laboratory, University Hospital, University of Missouri-Columbia, Columbia, MO 65212.
Richard D HammerClinical Flow Cytometry Laboratory, University Hospital, University of Missouri-Columbia, Columbia, MO 65212.
Diana GilDepartment of Molecular Microbiology & Immunology, School of Medicine, University of Missouri-Columbia, Columbia, MO 65212.
Adam G SchrumDepartment of Molecular Microbiology & Immunology, School of Medicine, University of Missouri-Columbia, Columbia, MO 65212.
Mayo Clinic · USUniversity of Missouri · USUniversity of Missouri Hospital · US

Funding

Human CD3epsilon co-potentiation to boost immunotherapyU01CA244314 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI GIL PAGES, DIANA · 2019 to 2024
$3.8M
Measuring multiprotein assemblies that drive biological signalsR01GM103841 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI SCHRUM, ADAM G. · 2013 to 2023
$3.3M
Mechanisms and consequences of CD3 rearrangement during TCR triggeringR01AI097187 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI GIL PAGES, DIANA · 2013 to 2018
$2.0M
NCI NIH HHS U01 CA244314NIAID NIH HHS R01 AI097187NIGMS NIH HHS R01 GM103841
6 · The paper itself

Abstract

During normal T cell development in mouse and human, a low-frequency population of immature CD4

Indexed as

CD8-Positive T-LymphocytesPrecursor T-Cell Lymphoblastic Leukemia-LymphomaReceptor, Notch1Receptors, Antigen, T-Cell, alpha-betaAnimalsCell DifferentiationHistocompatibility AntigensHumansMajor Histocompatibility ComplexMiceMice, Inbred C57BLMice, TransgenicMutationReceptors, Antigen, T-CellThymus GlandHistocompatibility AntigensReceptor, Notch1Receptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaleukemiaMHCNOTCHT-ALLTCR

Identifiers

PMID35767640
PMCPMC9271211
OpenAlexW4283695935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.