Evidence map›Paper›PMID 35767611›Full record

ArticleScience advances2022

Dynamic instability of dendrite tips generates the highly branched morphologies of sensory neurons.

Sonal Shree, Sabyasachi Sutradhar, Olivier Trottier, Yuhai Tu, Xin Liang, Jonathon Howard

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Population Morphology Implies a Common Developmental Blueprint forbioRxiv : the preprint server for biology · 2025
    Article
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  10. TheProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sonal ShreeDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-5665-8157
Sabyasachi SutradharDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-5826-5891
Olivier TrottierDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.ORCID 0000-0002-7437-4801
Yuhai TuIBM T.J. Watson Research Center, Yorktown Heights, NY 10598, USA.
Xin LiangTsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, 100084 Beijing, China.ORCID 0000-0001-7915-8094
Jonathon HowardDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.

Funding

Cell Biological Limitations Constrain Dendritic Branching Morphology and Neuronal FunctionDP1MH110065 · NIMH · YALE UNIVERSITY · PI HOWARD, JONATHON · 2015 to 2019
$4.2M
Dendrite structure: Data-Driven Models to Bridge from Molecules to MorphologyR01NS118884 · NINDS · YALE UNIVERSITY · PI HOWARD, JONATHON · 2021 to 2025
$2.0M
Molecular Mechanisms and Biochemical Circuits for Adaptation in Biological SystemsR35GM131734 · NIGMS · IBM THOMAS J. WATSON RESEARCH CENTER · PI TU, YUHAI · 2019 to 2024
$1.8M
NIGMS NIH HHS R35 GM131734NIMH NIH HHS DP1 MH110065NINDS NIH HHS R01 NS118884
6 · The paper itself

Abstract

The highly ramified arbors of neuronal dendrites provide the substrate for the high connectivity and computational power of the brain. Altered dendritic morphology is associated with neuronal diseases. Many molecules have been shown to play crucial roles in shaping and maintaining dendrite morphology. However, the underlying principles by which molecular interactions generate branched morphologies are not understood. To elucidate these principles, we visualized the growth of dendrites throughout larval development of

Identifiers

PMID35767611
PMCPMC9242452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.