Evidence map›Paper›PMID 35767128›Full record

ArticleMolecular diversity2023

Three-dimensional quantitative structural-activity relationship and molecular dynamics study of multivariate substituted 4-oxyquinazoline HDAC6 inhibitors.

Linan Zhao, Le Fu, Guangping Li, Yongxin Yu, Juan Wang, Haoran Liang, Mao Shu, Zhihua Lin, Yuanqiang Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linan ZhaoSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Le FuQianjiang Central Hospital of Chongqing, Chongqing, 409099, China.
Guangping LiSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Yongxin YuSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Juan WangSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Haoran LiangSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China. hrliang@cqut.edu.cn.
Mao ShuSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China. shumao@cqut.edu.cn.
Zhihua LinSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Yuanqiang WangSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China. wangyqnn@cqut.edu.cn.

Funding

State Key Laboratory of Silkworm Genome Biology Funded by State Key Laboratory of Silkworm Genome Biology, Science and Technology Bureau of Banan District, Chongqing sklsgb1819-2Support Program for Starting up Innovation Hub cx2020012
6 · The paper itself

Abstract

3D-QSAR models were established by collecting 46 multivariate-substituted 4-oxyquinazoline HDAC6 inhibitors. The relationship of molecular structure and inhibitory activity was studied by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA). The results showed the models established by CoMFA (q

Indexed as

Molecular Dynamics SimulationQuantitative Structure-Activity RelationshipMolecular Docking SimulationMolecular Structure3D-QSARDFTHistone deacetylase 6 inhibitorsMolecular dockingMolecular dynamics simulation

Identifiers

PMID35767128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.