Evidence map›Paper›PMID 35767071›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Measuring response in metastatic castration-resistant prostate cancer using PSMA PET/CT: comparison of RECIST 1.1, aPCWG3, aPERCIST, PPP, and RECIP 1.0 criteria.

Andrei Gafita, Isabel Rauscher, Wolfgang P Fendler, Vishnu Murthy, Wang Hui, Wesley R Armstrong, Ken Herrmann, Wolfgang A Weber, Jeremie Calais, Matthias Eiber and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 96 citations in OpenAlex.

  1. Trial
  2. Article
  3. The Prognostic Value ofAnnals of nuclear medicine · 2026
    Article
  4. PSMA-PET response under [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. coPERCIST: AI-assisted PET-CT response assessment.European journal of nuclear medicine and molecular imaging · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. FDG/PSMA discordance in [Frontiers in oncology · 2026
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Evaluating response to radium-223 usingAnnals of nuclear medicine · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Andrei GafitaAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Suite B114-61, Los Angeles, CA, 90095, USA. agafita@mednet.ucla.edu.ORCID 0000-0002-4865-9192
Isabel RauscherDepartment of Nuclear Medicine, Technical University Munich, Klinikum Rechts Der Isar, Munich, Germany.
Wolfgang P FendlerDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Vishnu MurthyAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Suite B114-61, Los Angeles, CA, 90095, USA.
Wang HuiDepartment of Nuclear Medicine, Technical University Munich, Klinikum Rechts Der Isar, Munich, Germany.
Wesley R ArmstrongAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Suite B114-61, Los Angeles, CA, 90095, USA.
Ken HerrmannDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Wolfgang A WeberDepartment of Nuclear Medicine, Technical University Munich, Klinikum Rechts Der Isar, Munich, Germany.
Jeremie CalaisAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Suite B114-61, Los Angeles, CA, 90095, USA.
Matthias EiberDepartment of Nuclear Medicine, Technical University Munich, Klinikum Rechts Der Isar, Munich, Germany.
Manuel WeberDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Matthias R BenzAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Suite B114-61, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · USTUM Klinikum · DEDeutschen Konsortium für Translationale Krebsforschung · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, the adapted Prostate Cancer Working Group Criteria 3 (aPCWG3), the adapted Positron Emission Tomography Response Criteria in Solid Tumors (aPERCIST), the PSMA PET Progression (PPP), and the Response Evaluation Criteria In PSMA-Imaging (RECIP) 1.0 for response evaluation using prostate-specific membrane antigen (PSMA)-PET/CT in men with metastatic castration-resistant prostate cancer (mCRPC) treated with

methodsA total of 124 patients were included in this multicenter retrospective study. All patients received

resultsA total of 43 (35%) of patients had non-measurable disease according to RECIST 1.1. Sixteen (13%), 66 (52%), 72 (58%), 69 (56%), and 39 (32%) of 124 patients had PD according to RECIST 1.1, aPCWG3, aPERCIST, PPP, and RECIP, respectively. PD vs no-PD had significantly higher risk of death according to aPCWG3 (HR = 2.37; 95%CI, 1.62-3.48; p < 0.001), aPERCIST (HR = 2.48; 95%CI, 1.68-3.66; p < 0.001), PPP (HR = 2.72; 95%CI, 1.85-4.01; p < 0.001), RECIP 1.0 (HR = 4.33; 95%CI, 2.80-6.70; p < 0.001), but not according to RECIST 1.1 (HR = 1.29; 95%CI, 0.73-2.27; p = 0.38). The κ index of RECIST 1.1, aPCWG3, aPERCIST 1.0, PPP, and RECIP 1.0 for identifying PD vs no-PD were 0.50 (95%CI, 0.32-0.76), 0.72 (95%CI, 0.63-0.82), 0.68 (95%CI, 0.63-0.73), 0.73 (95%CI, 0.63-0.83), and 0.83 (95%CI, 0.77-0.88), respectively.

conclusionPSMA-PET-specific criteria for early response evaluation in men with mCRPC treated with

Indexed as

Positron Emission Tomography Computed TomographyProstatic Neoplasms, Castration-ResistantDipeptidesHeterocyclic Compounds, 1-RingHumansLutetiumMalePositron-Emission TomographyProstate-Specific AntigenReproducibility of ResultsResponse Evaluation Criteria in Solid TumorsRetrospective StudiesTomography, X-Ray ComputedTreatment OutcomeDipeptidesHeterocyclic Compounds, 1-RingLutetiumProstate-Specific Antigen177Lu-PSMAPSMA PETRadionuclide treatmentResponse evaluationTheranostics

Identifiers

PMID35767071
OpenAlexW4283696470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.