Evidence map›Paper›PMID 35766716›Full record

ArticleBrazilian dental journal

Effect of nonsteroidal anti-inflammatory drugs (NSAIDs) association on physicochemical and biological properties of tricalcium silicate-based cement.

Maria Carolina Guiotti de Oliveira, Índia Olinta de Azevedo Queiroz, Thiago Machado, Lorena de Mello Alcântara Garrido, Sandra Helena Penha de Oliveira, Marco Antonio Hungaro Duarte

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian dental journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maria Carolina Guiotti de OliveiraDepartment of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, USP, Bauru, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-0073-005X
Índia Olinta de Azevedo QueirozDepartment of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, USP, Bauru, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-8214-0880
Thiago MachadoDepartment of Oral and Maxillofacial Surgery and Integrated Clinic, Araçatuba Dental School, UNESP, Araçatuba, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-5245-2629
Lorena de Mello Alcântara GarridoDepartment of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, USP, Bauru, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-7201-1505
Sandra Helena Penha de OliveiraDepartment of Basic Science, Araçatuba Dental School, UNESP, Araçatuba, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0805-1120
Marco Antonio Hungaro DuarteDepartment of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, USP, Bauru, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-3051-737X
Fundação de Apoio à Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the physicochemical and biological properties of an experimental tricalcium silicate-based repair cement containing diclofenac sodium (CERD). For the physicochemical test, MTA, Biodentine and CERD were mixed and cement disc were prepared to evaluate the setting time and radiopacity. Root-end cavity were performed in acrylic teeth and filled with cements to analyze the solubility up to 7 days. Polyethylene tubes containing cements were prepared and calcium ions and pH were measured at 3h, 24h, 72h and 15 days. For the biological test, SAOS-2 were cultivated, exposed to cements extracts and cell proliferation were investigated by MTT assay at 6h, 24h and 48h. Polyethylene tubes containing cements were implanted into Wistar rats. After 7 and 30 days, the tubes were removed and processed for histological analyses. Parametric and nonparametric data were performed. No difference was identified in relation to setting time, radiopacity and solubility. Biodentine released more calcium ion than MTA and CERD; however, no difference between MTA and CERD were detected. Alkaline pH was observed for all cements and Biodentine exhibited highest pH. All cements promoted a raise on cell proliferation at 24h and 48h, except CERD at 48h. Biodentine stimulated cell metabolism in relation to MTA and CERD while CERD was more cytotoxic than MTA at 48h. Besides, no difference on both inflammatory response and mineralization ability for all cement were found. CERD demonstrated similar proprieties to others endodontic cements available.

Indexed as

Aluminum CompoundsRoot Canal Filling MaterialsAnimalsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCalciumCalcium CompoundsDental CementsDrug CombinationsGlass Ionomer CementsMaterials TestingOxidesPolyethylenesRatsRats, WistarSilicatesAluminum CompoundsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCalciumCalcium CompoundsDental CementsDrug CombinationsGlass Ionomer CementsOxidesPolyethylenesRoot Canal Filling MaterialsSilicatestricalcium silicate

Identifiers

PMID35766716
PMCPMC9645202
OpenAlexW4283707249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.