Evidence map›Paper›PMID 35766403›Full record

ArticlemBio2022

Genetic Interaction Analysis Reveals that Cryptococcus neoformans Utilizes Multiple Acetyl-CoA-Generating Pathways during Infection.

Katy M Alden, Andrew J Jezewski, Sarah R Beattie, David Fox, Damian J Krysan

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. A Limited Number of Amino Acid Permeases Are Crucial forInternational journal of microbiology · 2024
    Review
  8. The Response ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katy M Alden *Department of Pediatrics Carver College of Medicine, University of Iowa, Iowa City Iowa, USA.
Andrew J Jezewski *Department of Pediatrics Carver College of Medicine, University of Iowa, Iowa City Iowa, USA.
Sarah R BeattieDepartment of Pediatrics Carver College of Medicine, University of Iowa, Iowa City Iowa, USA.
David FoxUCB Biosciences, Bainbridge Island, Washington, USA.
Damian J KrysanDepartment of Pediatrics Carver College of Medicine, University of Iowa, Iowa City Iowa, USA.ORCID 0000-0001-6330-3365
University of Iowa · USCenter for Infectious Disease Research · US

Funding

TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
Genetic and mechanistic analysis of carbon dioxide tolerance in Cryptococcus pathogenesisR01AI147541 · NIAID · UNIVERSITY OF IOWA · PI KRYSAN, DAMIAN J, LIN, XIAORONG · 2020 to 2025
$6.1M
Discovery and optimization of antifungal acetyl CoA synthetase inhibitorsR01AI161973 · NIAID · UNIVERSITY OF IOWA · PI KRYSAN, DAMIAN J · 2021 to 2025
$3.0M
Development of a high throughput-compatible assay for screening filamentous fungiF32AI145160 · NIAID · UNIVERSITY OF IOWA · PI BEATTIE, SARAH R. · 2020 to 2022
$185k
NIAID NIH HHS F32 AI145160NIAID NIH HHS HHSN272201700059CNIAID NIH HHS R01 AI147541NIAID NIH HHS R01 AI161973NIAID NIH HHS T32 AI007511
6 · The paper itself

Abstract

Cryptococcus neoformans is an important human fungal pathogen for which the external environment is its primary niche. Previous work has shown that two nonessential acetyl-CoA metabolism enzymes, ATP-citrate lyase (

Indexed as

CryptococcosisCryptococcus neoformansAcetyl Coenzyme AAnimalsCarbonHumansMammalsPhenotypeAcetyl Coenzyme ACarbonacetyl CoAcarbon metabolismCryptococcus neoformansfungal pathogenesis

Identifiers

PMID35766403
PMCPMC9426453
OpenAlexW4283717661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.