Evidence map›Paper›PMID 35766361›Full record

ArticleeLife2022

Connectomic analysis of the

Orie T Shafer, Gabrielle J Gutierrez, Kimberly Li, Amber Mildenhall, Daphna Spira, Jonathan Marty, Aurel A Lazar, Maria de la Paz Fernandez

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 91 citations in OpenAlex.

  1. Journal of biological rhythms · 2026
    Article
  2. Article
  3. Soma CaCurrent biology : CB · 2026
    Article
  4. Journal of biological rhythms · 2025
    Article
  5. A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Orie T Shafer *Advanced Science Research Center, The City University of New York, New York, United States.ORCID 0000-0001-7177-743X
Gabrielle J Gutierrez *Center for Theoretical Neuroscience, Zuckerman Institute, Columbia University, New York, United States.ORCID 0000-0002-2350-1559
Kimberly LiDepartment of Neuroscience and Behavior, Barnard College, New York, United States.
Amber MildenhallDepartment of Neuroscience and Behavior, Barnard College, New York, United States.ORCID 0000-0001-6495-8734
Daphna SpiraCenter for Theoretical Neuroscience, Zuckerman Institute, Columbia University, New York, United States.
Jonathan MartyDepartment of Electrical Engineering, Columbia University, New York, United States.
Aurel A LazarDepartment of Electrical Engineering, Columbia University, New York, United States.ORCID 0000-0003-4261-8709
Maria de la Paz FernandezDepartment of Neuroscience and Behavior, Barnard College, New York, United States.ORCID 0000-0002-9261-6114
Columbia University · USBarnard College · USThe Graduate Center, CUNY · US

Funding

Network Properties of Circadian Clock Modulation and EntrainmentR01NS077933 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ORIE T SHAFER · 2012 to 2026
$4.9M
Micro-Anatomical Mechanisms of Neuronal Circadian Timekeeping, Output, and EntrainmentR01NS118012 · NINDS · TRUSTEES OF INDIANA UNIVERSITY · PI SHAFER, ORIE T · 2021 to 2025
$2.1M
Effects of Local Adaptation on Parallel Pathway Circuit Computations in the RetinaK22NS104187 · NINDS · UNIVERSITY OF WASHINGTON · PI GUTIERREZ, GABRIELLE JACQUELINE · 2018 to 2024
$743k
NIH HHS K22 NS104187NINDS NIH HHS K22 NS104187NINDS NIH HHS R01 NS077933NINDS NIH HHS R01 NS118012
6 · The paper itself

Abstract

The circadian clock orchestrates daily changes in physiology and behavior to ensure internal temporal order and optimal timing across the day. In animals, a central brain clock coordinates circadian rhythms throughout the body and is characterized by a remarkable robustness that depends on synaptic connections between constituent neurons. The clock neuron network of

Indexed as

Circadian ClocksConnectomeDrosophila ProteinsPacemaker, ArtificialAnimalsCircadian RhythmDrosophilaDrosophila melanogasterMammalsNeuronsDrosophila Proteinscircadian rhythmsclock networksconnectomicsD. melanogasterneuroscience

Identifiers

PMID35766361
PMCPMC9365390
OpenAlexW4283735298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.