Evidence map›Paper›PMID 35766269›Full record

ArticleJournal of the American Heart Association2022

Sex-Specific Differences in Endothelial Function Are Driven by Divergent Mitochondrial Ca

Celio Damacena de Angelis, Benney T Endoni, Daniel Nuno, Kathryn Lamping, Johannes Ledolter, Olha M Koval, Isabella M Grumbach

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Mitochondrial CaCell calcium · 2025
    Article
  7. Effects of aging on calcium channels in skeletal muscle.Frontiers in molecular biosciences · 2025
    Review
  8. Review
  9. Metabolic Responses to Redox Stress in Vascular Cells.Antioxidants & redox signaling · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Celio Damacena de AngelisDepartment of Internal Medicine, Abboud Cardiovascular Research Center University of Iowa Iowa City IA.
Benney T EndoniDepartment of Internal Medicine, Abboud Cardiovascular Research Center University of Iowa Iowa City IA.ORCID 0000-0003-1078-3654
Daniel NunoDepartment of Internal Medicine, Abboud Cardiovascular Research Center University of Iowa Iowa City IA.
Kathryn LampingDepartment of Internal Medicine, Abboud Cardiovascular Research Center University of Iowa Iowa City IA.
Johannes LedolterTippie College of Business University of Iowa Iowa City IA.ORCID 0000-0002-0492-8434
Olha M KovalDepartment of Internal Medicine, Abboud Cardiovascular Research Center University of Iowa Iowa City IA.
Isabella M GrumbachDepartment of Internal Medicine, Abboud Cardiovascular Research Center University of Iowa Iowa City IA.ORCID 0000-0002-2285-3157
University of Iowa · US

Funding

Mitochondrial CaMKII drives smooth muscle migration and neointimal hyperplasiaR01HL108932 · NHLBI · UNIVERSITY OF IOWA · PI GRUMBACH, ISABELLA MARIA · 2012 to 2021
$3.6M
Mitochondrial CAMKII in smooth muscle as key regulator of hypertension and vascular remodelingI01BX000163 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI Isabella Maria Grumbach · 2011 to 2026
–
BLRD VA I01 BX000163NHLBI NIH HHS R01 HL108932
6 · The paper itself

Abstract

Background Sex-specific differences in vasodilation are mediated in part by differences in cytosolic Ca

Indexed as

CalciumCalcium ChannelsAnimalsEndothelial CellsEstradiolFemaleHumansMaleMiceMitochondriaSex CharacteristicsCalciumCalcium ChannelsEstradiolcalciummitochondrial Ca2+ uniportersex differencesvasoreactivity

Identifiers

PMID35766269
PMCPMC9333382
OpenAlexW4283691688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.