Evidence map›Paper›PMID 35766259›Full record

ReviewBirth defects research2022

Conjoined twins and conjoined triplets: At the heart of the matter.

Roelof-Jan Oostra, Annelieke N Schepens-Franke, Giovanni Magno, Alberto Zanatta, Lucas L Boer

Open access · hybridAbstract readReview
In one paragraph

Review in Birth defects research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Description of a monstrous little girl born in the Verona area on June 14, 1789.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Roelof-Jan OostraDepartment of Medical Biology, Section Clinical Anatomy & Embryology, Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, The Netherlands.ORCID 0000-0002-2452-8307
Annelieke N Schepens-FrankeDepartment of Imaging, Section Anatomy and Museum for Anatomy and Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Giovanni MagnoDepartment of Cardiac, Thoracic and Vascular Sciences, Section of Medical Humanities, Padua University Medical School and Museum of Pathological Anatomy, University Museums Centre, University of Padua, Padua, Italy.
Alberto ZanattaDepartment of Cardiac, Thoracic and Vascular Sciences, Section of Medical Humanities, Padua University Medical School and Museum of Pathological Anatomy, University Museums Centre, University of Padua, Padua, Italy.
Lucas L BoerDepartment of Imaging, Section Anatomy and Museum for Anatomy and Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-1564-0847
Radboud University Nijmegen · NLUniversity of Padua · ITAmsterdam UMC Location University of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conjoined triplets are among the rarest of human malformations, as are asymmetric or parasitic conjoined twins. Based on a very modest corpus of recent literature, we applied the embryonic disk model of conjoined twinning to 10 previously reported cases involving asymmetric anatomical multiplications to determine whether they concerned conjoined twins or conjoined triplets. In spite of their phenotypic similarities, we diagnosed four of these cases as conjoined twins and three of them as conjoined triplets. In the remaining three cases, no definite diagnosis could be made, as essential information was lacking from the reports. We conclude that it is not necessarily the expected duplication or triplication of structures that points to the correct diagnosis in these cases, but the number and mutual position of the hearts they presented with. Considering their rarity we stress to thoroughly investigate and describe internal (dys)morphology in novel cases of (asymmetric) conjoined twins and triplets to further unravel their pathogenicity and come to the correct diagnoses.

Indexed as

Twins, ConjoinedHeartHumanscongenital anomalyconjoined tripletsconjoined twinsembryologyembryonic disk modelheartteratology

Identifiers

PMID35766259
PMCPMC9546242
OpenAlexW4283695746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.