ArticleActa paediatrica (Oslo, Norway : 1992)2022
Lower iron stores were associated with suboptimal gross motor scores in infants at 3-7 months.
Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Longitudinal Plasma Ferritin in the First Year of Life in Relation to Maternal Status, Birth Characteristics, and Breastfeeding.Nutrients · 2026Observational
- Maternal and infant serum ferritin concentrations across pregnancy and postpartum: a longitudinal study in Norway.Food & nutrition research · 2026Article
- Measurement of iron absorption and iron gains from birth to 6 months in breastfed and formula-fed infants using iron isotope dilution.Science advances · 2024Article
- A Retrospective Evaluation of the Predictive Value of Newborn Screening for Vitamin B12 Deficiency in Symptomatic Infants Below 1 Year of Age.International journal of neonatal screening · 2022Article
- Nitrous oxide in labour predicted newborn screening total homocysteine and is a potential risk factor for infant vitamin B12 deficiency.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Lower iron stores were associated with suboptimal gross motor scores in infants at 3-7 months.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate associations between iron status and gross motor scores in infants aged 3-7 months.
methodsIn a prospective study, 252 infants aged 3-7 months were examined using the age-standardised Alberta Infant Motor Scale (AIMS) prior to analysing iron status in 250 infants. Combined AIMS and ferritin results were assessed in 226 infants, whereas AIMS and reticulocyte haemoglobin (ret-Hb) results were obtained for 61 infants. We used logistic regressions and receiver operator characteristics to analyse our data.
resultsWith AIMS z-score <10th percentile as outcome measure, optimal cut-off value for ferritin was 51 μg/L (sensitivity 86%, specificity 81%) and 28 pg for ret-Hb (sensitivity 86%, specificity 85%). The area under the curve for ferritin and ret-Hb was 0.886 and 0.896, respectively (n = 61). Ferritin <51 μg/L predicted an AIMS z-score <10th percentile in a logistic regression (OR 3.3, 95% CI 1.4-7.5, p = 0.006, n = 226). Six of 14 (43%) infants with ret-Hb <28 pg scored <10th percentile on AIMS compared to 1/47 (2.1%) infants with ret-Hb ≥28 μg/L (Exact, p < 0.001).
conclusionReticulocyte haemoglobin of <28 pg and ferritin <51 μg/L were associated with suboptimal gross motor scores in infants 3-7 months.
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