Evidence map›Paper›PMID 35765878›Full record

ArticleAnnals of laboratory medicine2022

Immunogenicity of Third-dose BNT162b2 mRNA Vaccine Following Two Doses of ChAdOx1 in Health Care Workers: A Prospective Longitudinal Study.

Jung-Ah Kim, Hae In Bang, Jeong Won Shin, Yoonhye Park, Saerom Kim, Mi-Young Kim, Eui Young Jang, Woo Yong Shin, Jieun Kim, Rojin Park and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Annals of laboratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jung-Ah KimDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-1295-4728
Hae In BangDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-7854-3011
Jeong Won ShinDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-6913-4793
Yoonhye ParkDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-2209-9609
Saerom KimDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-2906-2948
Mi-Young KimDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-8359-2392
Eui Young JangDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-5411-6293
Woo Yong ShinDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-5588-6919
Jieun KimDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-7794-3475
Rojin ParkDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-2866-037X
Tae Youn ChoiDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-1950-8010
Soonchunhyang University Hospital Seoul · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the original severe acute respiratory syndrome coronavirus 2 strain (Wuhan-Hu-1) in December 2019, the Delta variant in May 2021 and the Omicron variant in December 2021 were classified as variants of concern. The pandemic has been ongoing for more than two years, and the three-dose vaccination rate has reached approximately 50% in Korea. We analyzed anti-S antibodies (Abs) and neutralizing Abs (NAbs) in 32 healthcare workers at a university hospital, focusing on the first to third doses of ChAdOx1-ChAdOx1-BNT162b2, which is the most common vaccination regimen in Korea. Antibodies were analyzed at eight time points according to the vaccine regimen. The first to third doses of ChAdOx1-ChAdOx1-BNT162b2 produced high Ab concentrations; NAb concentrations after the third dose were predicted to remain high for a longer period than those after the first and second doses. The effectiveness of a second dose of ChAdOx1 in the real world was demonstrated by analyzing samples collected during an outbreak that occurred in the study period, 4-5 months after the second dose. The relative risk ratio was 88.0%, and the efficacy of the second ChAdOx1 dose was 12.0% (

Indexed as

BNT162 VaccineCOVID-19Health PersonnelHumansLongitudinal StudiesmRNA VaccinesProspective StudiesSARS-CoV-2Vaccines, SyntheticBNT162 VaccinemRNA VaccinesVaccines, SyntheticAnti-S antibodyBNT162b2ChAdOx1COVID-19Neutralizing antibodyThree-dose vaccination

Identifiers

PMID35765878
PMCPMC9277035
OpenAlexW4283687122

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.