Evidence map›Paper›PMID 35765805›Full record

ReviewJournal of the Royal Society, Interface2022

May the 4C's be with you: an overview of complexity-inspired frameworks for analysing resting-state neuroimaging data.

Fran Hancock, Fernando E Rosas, Pedro A M Mediano, Andrea I Luppi, Joana Cabral, Ottavia Dipasquale, Federico E Turkheimer

Abstract readReview
In one paragraph

Review in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Structured Dynamics in the Algorithmic Agent.Entropy (Basel, Switzerland) · 2025
    Article
  3. Flow and intuition: a systems neuroscience comparison.Neuroscience of consciousness · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fran HancockDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-7383-7205
Fernando E RosasCentre for Psychedelic Research, Department of Brain Science, Imperial College London, London SW7 2DD, UK.ORCID 0000-0001-7790-6183
Pedro A M MedianoDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.ORCID 0000-0003-1789-5894
Andrea I LuppiDivision of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3461-6431
Joana CabralLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0002-6715-0826
Ottavia DipasqualeDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Federico E TurkheimerDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Funding

Wellcome Trust 210920/Z/18/Z
6 · The paper itself

Abstract

Competing and complementary models of resting-state brain dynamics contribute to our phenomenological and mechanistic understanding of whole-brain coordination and communication, and provide potential evidence for differential brain functioning associated with normal and pathological behaviour. These neuroscientific theories stem from the perspectives of physics, engineering, mathematics and psychology and create a complicated landscape of domain-specific terminology and meaning, which, when used outside of that domain, may lead to incorrect assumptions and conclusions within the neuroscience community. Here, we review and clarify the key concepts of connectivity, computation, criticality and coherence-the 4C's-and outline a potential role for metastability as a common denominator across these propositions. We analyse and synthesize whole-brain neuroimaging research, examined through functional magnetic imaging, to demonstrate that complexity science offers a principled and integrated approach to describe, and potentially understand, macroscale spontaneous brain functioning.

Indexed as

NeuroimagingNeurosciencesBrainHeadPhysicscomplexitycomputationconnectivitycriticalityintegrated informationmetastability

Identifiers

PMID35765805
PMCPMC9240685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.