Evidence map›Paper›PMID 35765714›Full record

ArticleESC heart failure2022

Causal associations between sleep traits and four cardiac diseases: a Mendelian randomization study.

Yongli Yang, Jingwen Fan, Xuezhong Shi, Yuping Wang, Chaojun Yang, Jiao Lian, Nana Wang, Chenyu Zhao, Yang Zhao, Xiaocan Jia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Associations between insomnia and cardiovascular diseases: a meta-review and meta-analysis of observational and Mendelian randomization studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
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  7. Age-Related Macular Degeneration and Circadian Preference.Clinical ophthalmology (Auckland, N.Z.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yongli YangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Jingwen FanDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Xuezhong ShiDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Yuping WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Chaojun YangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Jiao LianDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Nana WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Chenyu ZhaoDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Yang ZhaoDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Xiaocan JiaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Zhengzhou University · CNZhengzhou University of Science and Technology · CN

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

aimsPrevious studies investigated the associations between sleep traits and cardiac diseases, but the evidence for the causal inferences was unclear. This study aimed to explore the causal relationship between sleep and cardiac diseases by virtue of Mendelian randomization (MR). METHODS AND

resultsSummary-level data for exposure variables (sleep duration, chronotype, and insomnia) and outcome variables (ischaemic heart disease, atrial fibrillation, myocardial infarction, and heart failure) were derived from UK Biobank. Data from the FinnGen consortium was used as a robustness check. In MR analysis, the inverse variance weighted (IVW) method was applied to infer causality between exposure and outcome. MR-Egger regression was used to identify pleiotropy, and MR-PRESSO outlier test was used to remove the pleiotropy of the genetic instruments. Based on UK Biobank, MR analysis suggested that sleep duration was weakly associated with atrial fibrillation (OR = 0.9999, 95% CI: 0.9998-0.9999) and ischaemic heart disease (OR = 0.9997, 95% CI: 0.9995-0.9998). Insomnia was associated with ischaemic heart disease (OR = 1.0117, 95% CI: 1.0051-1.0183) and myocardial infarction (OR = 1.0049, 95% CI: 1.0019-1.0079). No associations were found between chronotype and cardiac diseases (P > 0.05). We did not find pleiotropy except for insomnia with ischaemic heart disease and myocardial infarction using MR-Egger regression, and MR-PRESSO analysis consistent with IVW. Finally, we obtained the same direction as with UK Biobank using the FinnGen data.

conclusionsSleep duration and insomnia might be the potential causal risk factors of cardiac diseases. As the OR was small, these associations are probably not clinically relevant. Further validation studies are needed.

Indexed as

Atrial FibrillationCoronary Artery DiseaseMyocardial InfarctionSleep Initiation and Maintenance DisordersHumansMendelian Randomization AnalysisSleepCardiac diseaseCausal relationshipMendelian randomizationSleep

Identifiers

PMID35765714
PMCPMC9715768
OpenAlexW4283699100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.