Evidence map›Paper›PMID 35765545›Full record

ArticleRegenerative therapy2022

Transplantation of human cells into Interleukin-2 receptor gamma gene knockout pigs under several conditions.

Koki Hasegawa, Kazuaki Nakano, Masaki Nagaya, Masahito Watanabe, Ayuko Uchikura, Hitomi Matsunari, Kazuhiro Umeyama, Eiji Kobayashi, Hiroshi Nagashima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Koki HasegawaLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan.
Kazuaki NakanoPorMedTec Co. Ltd., 2-3227 MIta, Tama-ku, Kawasaki, Kanagawa, 214-0034, Japan.
Masaki NagayaMeiji University International Institute for Bio-Resource Research, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan.
Masahito WatanabePorMedTec Co. Ltd., 2-3227 MIta, Tama-ku, Kawasaki, Kanagawa, 214-0034, Japan.
Ayuko UchikuraLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan.
Hitomi MatsunariLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan.
Kazuhiro UmeyamaPorMedTec Co. Ltd., 2-3227 MIta, Tama-ku, Kawasaki, Kanagawa, 214-0034, Japan.
Eiji KobayashiDepartment of Kidney Regenerative Medicine, The Jikei University School of Medicine - Tokyo, Japan.
Hiroshi NagashimaLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan.
Meiji University · JPJikei University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Previously, we performed gene knockout (KO) of interleukin-2 receptor gamma ( Methods: The Results: Tumors from the transplanted cells quickly developed in all pigs and were verified by histology and immunohistochemistry. We also transplanted these cells into the pancreas of designated pathogen-free pigs housed in novel biocontainment facilities, and large tumors were confirmed. Conclusions:

Indexed as

DPF, designated pathogen-freeIL2RG, interleukin-2 receptor gammaIL, InterleukinInterleukin-2 receptor gammaKO, knock out pigsNK cells, natural killer cellsOIDP, operational immunodeficient pigPCR, polymerase chain reactionPigSCIDSCID, Severe combined immunodeficiencySCNT, somatic cell nuclear transferSD, standard deviationtdTomato, tandem dimer TomatoU-iR, uterectomy-isolated rearingWT, wild-type pigsXenotransplantationXLGD, X-linked genetic diseasesZFN, Zinc finger nuclease

Identifiers

PMID35765545
PMCPMC9198816
OpenAlexW4281762057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.