Evidence map›Paper›PMID 35765543›Full record

ReviewComputational and structural biotechnology journal2022

Severe acute respiratory syndrome coronavirus 2 variants-Possibility of universal vaccine design: A review.

Eunhye Yoon, Dahyun Kim, Hyeeun Jeon, Yejin Kwon, Yejin Jang, Sulhee Kim, Kwang Yeon Hwang

Abstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Coordination chemistry suggests that independently observed benefits of metformin and ZnBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eunhye YoonDivision of Biotechnology, College of Life Sciences and Biotechnology, Seoul 02841, South Korea.
Dahyun KimDivision of Biotechnology, College of Life Sciences and Biotechnology, Seoul 02841, South Korea.
Hyeeun JeonDivision of Biotechnology, College of Life Sciences and Biotechnology, Seoul 02841, South Korea.
Yejin KwonDivision of Biotechnology, College of Life Sciences and Biotechnology, Seoul 02841, South Korea.
Yejin JangDivision of Biotechnology, College of Life Sciences and Biotechnology, Seoul 02841, South Korea.
Sulhee KimDivision of Biotechnology, College of Life Sciences and Biotechnology, Seoul 02841, South Korea.
Kwang Yeon HwangDivision of Biotechnology, College of Life Sciences and Biotechnology, Seoul 02841, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both novel and conventional vaccination strategies have been implemented worldwide since the onset of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite various medical advances in the treatment and prevention of the spread of this contagious disease, it remains a major public health threat with a high mortality rate. As several lethal SARS-CoV-2 variants continue to emerge, the development of several vaccines and medicines, each with certain advantages and disadvantages, is underway. Additionally, many modalities are at various stages of research and development or clinical trials. Here, we summarize emerging SARS-CoV-2 variants, including delta, omicron, and "stealth omicron," as well as available oral drugs for COVID-19. We also discuss possible antigen candidates other than the receptor-binding domain protein for the development of a universal COVID-19 vaccine. The present review will serve as a helpful resource for future vaccine and drug development to combat COVID-19.

Indexed as

ACE2, angiotensin-converting enzyme 2AntigenCoronavirusCOVID-19COVID-19, coronavirus disease 2019FDA, Food and Drug AdministrationFP, fusion peptideHE, hemagglutinin-esteraseHIV, human immunodeficiency virusHR1, heptad repeat 1HR2, heptad repeat 2mAbs, monoclonal antibodiesOral drugRBD, receptor binding domainReceptor-binding domainS1-CTD, S1 C-terminal domainS1-NTD, S1 N-terminal domainSARS-CoV-2, severe acute respiratory syndrome coronavirus 2TMPRSS2, transmembrane protease serine 2Universal vaccine

Identifiers

PMID35765543
PMCPMC9221512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.