ArticlePediatrics2022
Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C.
Article in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Long-Term Complications of Multisystem Inflammatory Syndrome in Children and Adults Post-COVID-19: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Pediatric post COVID-19 condition: an umbrella review of the most common symptoms and associated factors.European journal of public health · 2024Pooled it
- Risk factors for long COVID in children and adolescents: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2024Pooled it
- Management of long COVID-19 in children and adolescents: from diagnosis to therapeutically approaches.Annals of medicine · 2026Review
- The Burden of Long-COVID-19 Among Pediatric Subjects: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Clinical symptom score and risk factors for predicting post-acute sequelae of SARS-CoV-2 infection in children hospitalized with COVID-19 in Taiwan.BMC infectious diseases · 2026Article
- Risk factors for severe post-COVID condition in children, adolescents, and young adults.European journal of pediatrics · 2026Observational
- A Predictive Model for the Development of Long COVID in Children.International journal of environmental research and public health · 2025Article
- Neurologic and Psychological Outcomes 2 Years After Multisystem Inflammatory Syndrome in Children.JAMA network open · 2025Article
- Consensus based recommendations for the management of post-COVID long-term sequelae (Long COVID): a regional perspective.Frontiers in medicine · 2025Article
- Prevalence and duration of clinical symptoms of pediatric long COVID: findings from a one-year prospective study.Frontiers in pediatrics · 2025Article
- Postacute Sequelae of COVID-19 in Pediatric Patients Within the United States: A Scoping Review.American journal of medicine open · 2024Article
- Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Postacute Sequelae of SARS-CoV-2 in Children.Pediatrics · 2024Review
- Short-term and medium-term clinical outcomes of multisystem inflammatory syndrome in children: a prospective observational cohort study.Italian journal of pediatrics · 2024Observational
- Post-discharge outcomes of hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C.Frontiers in pediatrics · 2024Article
- Clinical and healthcare utilization outcomes during the 6 months following COVID infection in children.Pediatric research · 2024Article
- Review
- Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: Common Inflammatory Pathways of Two Distinct Diseases.Rheumatic diseases clinics of North America · 2023Review
- Neurological and Psychological Sequelae Associated With Multisystem Inflammatory Syndrome in Children.JAMA network open · 2023Article
Corrections and comments
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Authors and funding
41 authors at 20 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C).
methodsMulticenter prospective cohort study conducted in 25 United States pediatric hospitals. Patients <21-years-old, hospitalized May 2020 to May 2021 for acute COVID-19 or MIS-C with follow-up 2 to 4 months after admission. We assessed readmissions, persistent symptoms or activity impairment, and new morbidities. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).
resultsOf 358 eligible patients, 2 to 4 month survey data were available for 119 of 155 (76.8%) with acute COVID-19 and 160 of 203 (78.8%) with MIS-C. Thirteen (11%) patients with acute COVID-19 and 12 (8%) with MIS-C had a readmission. Thirty-two (26.9%) patients with acute COVID-19 had persistent symptoms (22.7%) or activity impairment (14.3%) and 48 (30.0%) with MIS-C had persistent symptoms (20.0%) or activity impairment (21.3%). For patients with acute COVID-19, persistent symptoms (aRR, 1.29 [95% CI, 1.04-1.59]) and activity impairment (aRR, 1.37 [95% CI, 1.06-1.78]) were associated with more organ systems involved. Patients with MIS-C and pre-existing respiratory conditions more frequently had persistent symptoms (aRR, 3.09 [95% CI, 1.55-6.14]) and those with obesity more frequently had activity impairment (aRR, 2.52 [95% CI, 1.35-4.69]). New morbidities were infrequent (9% COVID-19, 1% MIS-C).
conclusionsOver 1 in 4 children hospitalized with acute COVID-19 or MIS-C experienced persistent symptoms or activity impairment for at least 2 months. Patients with MIS-C and respiratory conditions or obesity are at higher risk of prolonged recovery.
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