Evidence map›Paper›PMID 35764993›Full record

ArticleBMC oral health2022

Role of NOD2 and hepcidin in inflammatory periapical periodontitis.

Jing Hu, Marie Aimee Dusenge, Qin Ye, Ya-Qiong Zhao, Li Tan, Yao Feng, Jie Zhao, Zheng-Rong Gao, Shao-Hui Zhang, Yun Chen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jing Hu *Department of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Marie Aimee Dusenge *Department of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Qin YeDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Ya-Qiong ZhaoDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Li TanDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Yao FengDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Jie ZhaoDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Zheng-Rong GaoDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Shao-Hui ZhangDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Yun ChenDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Ying-Hui ZhouNational Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Yue GuoDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. guoyue@csu.edu.cn.
Yun-Zhi FengDepartment of Stomatology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. fengyunzhi001@csu.edu.cn.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immunological response occurring during periapical inflammation includes expression of nucleotide binding oligomerization domain containing 2 and hepcidin. Nucleotide binding oligomerization domain containing 2 deficiency increases infiltration of inflammatory cells close to alveolar bone. Hepcidin has an important role in iron metabolism affecting bone metabolism.We investigated the role of nucleotide binding oligomerization domain containing 2 and hepcidin in inflammatory periapical periodontitis. Periapical periodontitis was induced in rats and confirmed by micro-computed tomography. Nucleotide binding oligomerization domain 2 and hepcidin were evaluated through immunohistochemistry. Bioinformatics analysis was undertaken usingthe Kyoto Encyclopedia of Genes and Genomes and Gene Ontology databases. Micro-computer tomography revealed alveolar bone resorption in the periapical region and furcation area of mandibular molars in rats of the periapical periodontitis group. Immunohistochemistry showed increased expressionof nucleotide binding oligomerization domain containing 2 and hepcidin around root apices in rats of the periapical periodontitis group. Bioinformatics analysis of differentially expressed genes in inflamed and non-inflamed tissues revealed enrichment in the NOD-like receptor signaling pathway. Our data suggest that nucleotide binding oligomization domain contain2 and hepcidin have important roles in periapical periodontitis severity because they can reduce alveolar bone loss.They could elicit new perspectives for development of novel strategies for periapical periodontitis treatment.

Indexed as

HepcidinsNod2 Signaling Adaptor ProteinPeriapical PeriodontitisAlveolar Bone LossAnimalsNucleotidesRatsX-Ray MicrotomographyHepcidinsNOD2 protein, ratNod2 Signaling Adaptor ProteinNucleotidesHepcidinInflammationNOD2Periapical periodontitis

Identifiers

PMID35764993
PMCPMC9241313
OpenAlexW4283651409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.