ArticleBMC geriatrics2022
Osteosarcopenic obesity and its components-osteoporosis, sarcopenia, and obesity-are associated with blood cell count-derived inflammation indices in older Chinese people.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Association between immune-inflammatory index and osteoporosis: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- A comprehensive meta-analysis of risk factors associated with osteosarcopenic obesity: a closer look at gender, lifestyle and comorbidities.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- Association of composite inflammatory indicators with osteoporosis and sarcopenia in type 2 diabetes mellitus: the mediating role of inflammation.Journal of endocrinological investigation · 2026Article
- Time-Dependent Effect of Anti-seizure Medications on Bone Metabolism in Patients with Epilepsy: A Cross-Sectional Study.Neurology and therapy · 2026Article
- Association between lymphocyte to high-density lipoprotein ratio and total bone mineral density in 8-19-year-old children and adolescents: a cross-sectional study.European journal of medical research · 2026Article
- Osteosarcopenic obesity and the progression of physical frailty, cognition function, and mental health: First longitudinal evidence from ELSA.The journal of nutrition, health & aging · 2026Article
- Association Between Sarcopenia Index and Central Obesity: Age- and Gender-Specific Patterns and Clinical Implications.International journal of general medicine · 2026Article
- Systemic inflammation markers and the prevalence of osteoporosis and osteopenia: A NHANES cross-sectional study.Journal of family medicine and primary care · 2025Article
- Associations of cadmium exposure within heavy metal combinations with osteoporosis risk: an analysis of NHANES data (2013-2014 and 2017-2018).Aging clinical and experimental research · 2025Article
- Association of Sarcopenic Obesity and Osteoporosis in Postmenopausal Women: Risk Factors and Protective Effects of Hormonal Therapy and Nutritional Status.Archives of osteoporosis · 2025Article
- Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016.Frontiers in endocrinology · 2025Article
- Beyond linearity: a threshold effect links serum creatinine to SIRI in osteoporotic fractures.Frontiers in medicine · 2025Article
- Associations between sarcopenia (defined by low muscle mass), inflammatory markers, and all-cause mortality in older adults: mediation analyses in a large U.S. NHANES community sample, 1999-2006.Frontiers in medicine · 2025Article
- Cumulative behavioral and metabolic determinants of health are associated with higher inflammation-related indices: insights from a cross-sectional study (NHANES 2005-2018).Frontiers in public health · 2025Article
- From Inflammation to Bone Loss: The Multifaceted Role of Neutrophils in Osteoporosis.International journal of inflammation · 2025Review
- The Role of Inflammatory and Nutritional Indices in Postmenopausal Osteoporosis: A Retrospective Study.Journal of clinical medicine · 2024Article
- Association between modified dietary inflammation index score and lumbar vertebrae bone mineral density in patients with hypertension: data from NHANES-a population-based study.Nutrition & metabolism · 2024Article
- Association between inflammation-related indicators and vertebral fracture in older adults in the United States: A cross-sectional study based on National Health and Nutrition Examination Survey 2013-2014.Immunity, inflammation and disease · 2024Article
- Higher CALLY index levels indicate lower sarcopenia risk among middle-aged and elderly community residents as well as hospitalized patients.Scientific reports · 2024Article
- Prevalence of Osteosarcopenic Adiposity in Apparently Healthy Adults and Appraisal of Age, Sex, and Ethnic Differences.Journal of personalized medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the associations of osteosarcopenic obesity (OSO) and its components with complete blood cell count-derived inflammation indices.
methodsIn this cross-sectional study, data of 648 participants aged ≥60 years (men/women: 232/416, mean age: 67.21 ± 6.40 years) were collected from January 2018 to December 2020. Areal bone mineral density and body fat percentage were used to define osteopenia/osteoporosis and obesity, respectively. The criteria of the 2019 Asian Working Group for Sarcopenia were used to diagnose sarcopenia. Based on the number of these conditions, participants were divided into four groups: OSO/0, OSO/1, OSO/2, and OSO/3. Logistic regression analysis was conducted to identify associations between blood cell count-derived inflammation indices and the number of disorders with abnormal body composition.
resultsSystemic inflammation response index (SIRI), white blood cells, neutrophil-to-lymphocyte ratio (NLR), aggregate inflammation systemic index (AISI), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) showed statistically significant differences among the four groups (P < 0.05). Unlike in the OSO/0 group, in all other groups, AISI, SIRI, PLR, and NLR were significantly associated with increased likelihood of having multiple disorders with abnormal body composition after adjustment for confounders (P < 0.0001 for all). However, LMR showed an inverse correlation with the number of these conditions (P < 0.05).
conclusionHigher SIRI, AISI, NLR, and PLR values and lower LMR values are closely associated with OSO and its individual components-osteoporosis, sarcopenia, and obesity-in older adults, suggesting that the value of these indices in the evaluation of OSO warrants further investigation.
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