Evidence map›Paper›PMID 35764940›Full record

ArticleBMC pregnancy and childbirth2022

Placental morphology in association with autism-related traits in the EARLI study.

Caichen Zhong, Ruchit Shah, Juliette Rando, Bo Park, Theresa Girardi, Cheryl K Walker, Lisa A Croen, M Daniele Fallin, Irva Hertz-Picciotto, Brian K Lee and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Caichen ZhongDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, 19104, USA. cz358@drexel.edu.
Ruchit ShahPlacental Analytics, New Rochelle, NY, USA.
Juliette RandoAJ Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Bo ParkDepartment of Public Health, California State University Fullerton, Fullerton, CA, USA.
Theresa GirardiPlacental Analytics, New Rochelle, NY, USA.
Cheryl K WalkerDepartment of Obstetrics and Gynecology, University of California Davis Health, Sacramento, CA, USA.
Lisa A CroenDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
M Daniele FallinDepartment of Mental Health, Johns Hopkins University, Baltimore, MD, USA.
Irva Hertz-PicciottoDepartment of Public Health Sciences and the MIND Institute, School of Medicine, University of California Davis, Davis, CA, USA.
Brian K LeeDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, 19104, USA.
Rebecca J SchmidtDepartment of Public Health Sciences and the MIND Institute, School of Medicine, University of California Davis, Davis, CA, USA.
Heather E VolkDepartment of Mental Health, Johns Hopkins University, Baltimore, MD, USA.
Craig J NewschafferDepartment of Health and Human Development, Pennsylvania State University, University Park, PA, USA.
Carolyn M Salafia *Placental Analytics, New Rochelle, NY, USA.
Kristen Lyall *AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Drexel University · USUniversity of California, Davis · USJohns Hopkins University · USCalifornia State University, Fullerton · USKaiser Permanente · USPennsylvania State University · US

Funding

Early Autism Risk Longitudinal Investigation (EARLI) NetworkR01ES016443 · NIEHS · DREXEL UNIVERSITY · PI NEWSCHAFFER, CRAIG J · 2008 to 2013
$15.6M
Oxidative stress pathways and placental pathology in association with autism spectrum disorder and neurodevelopmentR21HD096356 · NICHD · DREXEL UNIVERSITY · PI LYALL, KRISTEN · 2018 to 2019
$434k
Autism Speaks AS 5938Autism Speaks AS5938National Institute of Child Health and Human Development HD096356-01National Institute of Environmental Health Sciences, the National Institute of Mental Health, the National Institute of Child Health and Human Development, and the National Institute of Neurologic Disease and Stroke ES016443NICHD NIH HHS R21 HD096356NIEHS NIH HHS R01 ES016443
6 · The paper itself

Abstract

backgroundIn prior work we observed differences in morphology features in placentas from an autism-enriched cohort as compared to those from a general population sample. Here we sought to examine whether these differences associate with ASD-related outcomes in the child.

methodsParticipants (n = 101) were drawn from the Early Autism Risk Longitudinal Investigation (EARLI), a cohort following younger siblings of children with autism spectrum disorder (ASD). ASD-related outcomes, including the Social Responsiveness Scale (SRS), Mullen Scales of Early Learning (MSEL) Early Learning Composite, and ASD diagnosis, were assessed at age 3. Crude and adjusted linear regression was used to examine associations between placental morphological features (parametrized continuously and in quartiles) and SRS and MSEL scores; comparisons by ASD case status were explored as secondary analyses due to the small number of cases (n = 20).

resultsIn adjusted analyses, we observed a modest positive association between umbilical cord eccentricity, defined as the ratio of the maximum:minimum radius from the cord insertion point, and SRS scores (Beta = 1.68, 95%CI = 0.45, 2.9). Positive associations were also suggested between placental maximum thickness and cord centrality and SRS scores, though these were estimated with little precision. Associations between other placental morphological features and outcomes were not observed.

conclusionsOur analyses suggested a potential association between umbilical cord features and ASD-related traits, of interest as non-central cord insertion may reflect reduced placenta efficiency. Future studies with larger sample sizes are needed to further examine these and other placental features in association with ASD-related outcomes.

Indexed as

Autism Spectrum DisorderAutistic DisorderChildChild, PreschoolFemaleHumansLongitudinal StudiesPlacentaPregnancySiblingsAutism-related traitsAutism spectrum disorderCluster analysisPlacental morphologyPlacental thicknessUmbilical cord

Identifiers

PMID35764940
PMCPMC9241175
OpenAlexW4283652705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.