ArticleHeredity2022
Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales.
Article in Heredity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- A maternal effect shapes early-life adaptive body size variation in house mice.bioRxiv : the preprint server for biology · 2026Article
- Multiple Eurasian Origins and Admixture Shaped the Genomic Legacy of the House Mouse Invasion in Africa.Molecular ecology · 2026Article
- Regionally specific and highly pleiotropic loci together mediate skeletal evolution in tropical and temperate house mice.Genetics · 2026Article
- Elevated lysosomal mass and enzyme activity in fibroblasts of the Mediterranean mouse Mus spretus.Biology letters · 2026Article
- Article
- Predicting functional constraints across evolutionary timescales with phylogeny-informed genomic language models.bioRxiv : the preprint server for biology · 2025Article
- Population Genomics of Giant Mice from the Faroe Islands: Hybridization, Colonization, and a Novel Challenge to Identifying Genomic Targets of Selection.Genome biology and evolution · 2025Article
- Phenogenomic resources immortalized in a panel of wild-derived strains of five species of house mice.Scientific reports · 2025Article
- Genetic structure and demographic history of house mice in western Europe inferred using whole-genome sequences.Proceedings. Biological sciences · 2025Article
- Persistence, spillover, and evolution of co-occurring lineages of lymphocytic choriomeningitis virus.Virus evolution · 2025Article
- Article
- Across two continents: The genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas.PLoS genetics · 2024Article
- Article
- Tissue-specific and cis-regulatory changes underlie parallel, adaptive gene expression evolution in house mice.PLoS genetics · 2024Article
- Across two continents: the genomic basis of environmental adaptation in house mice (bioRxiv : the preprint server for biology · 2023Article
- Environmentally robustProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The demographic history of house mice (Mus musculus domesticus) in eastern North America.G3 (Bethesda, Md.) · 2023Article
- Article
- Rodent gene drives for conservation: opportunities and data needs.Proceedings. Biological sciences · 2019Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
House mice (Mus musculus) have spread globally as a result of their commensal relationship with humans. In the form of laboratory strains, both inbred and outbred, they are also among the most widely used model organisms in biomedical research. Although the general outlines of house mouse dispersal and population structure are well known, details have been obscured by either limited sample size or small numbers of markers. Here we examine ancestry, population structure, and inbreeding using SNP microarray genotypes in a cohort of 814 wild mice spanning five continents and all major subspecies of Mus, with a focus on M. m. domesticus. We find that the major axis of genetic variation in M. m. domesticus is a south-to-north gradient within Europe and the Mediterranean. The dominant ancestry component in North America, Australia, New Zealand, and various small offshore islands are of northern European origin. Next we show that inbreeding is surprisingly pervasive and highly variable, even between nearby populations. By inspecting the length distribution of homozygous segments in individual genomes, we find that inbreeding in commensal populations is mostly due to consanguinity. Our results offer new insight into the natural history of an important model organism for medicine and evolutionary biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.