ArticleNPJ Parkinson's disease2022
Simulating the progression of brain structural alterations in Parkinson's disease.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Linking cortical morphology and neurophysiological dynamics in Parkinson's disease.Scientific reports · 2026Article
- Impact of tractogram filtering and graph creation for structural connectomics in subjects with Parkinson's disease.Frontiers in human neuroscience · 2026Article
- Linking Cortical Morphology and Neurophysiological Dynamics in Parkinson's Disease.Research square · 2025Article
- Impaired Glymphatic Clearance, Measured Using Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS), is Linked to Poor Cognitive Outcomes in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Multivariate Associations Between Neurophysiological Activity and Sensory Motor Cortical Morphometry in Parkinson's Disease.bioRxiv : the preprint server for biology · 2025Article
- Early Alterations in De Novo Parkinson's Disease Revealed by Diffusion Tensor Imaging: Preliminary Study.Diagnostics (Basel, Switzerland) · 2025Article
- Brain structural MRI marker for predicting conversion to Parkinson's disease in individuals with prodromal symptoms.Frontiers in aging neuroscience · 2025Article
- Multimodal neuroimaging to characterize symptom-specific networks in movement disorders.NPJ Parkinson's disease · 2024Review
- Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions.Nature communications · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Considering brain structural alterations as neurodegenerative consequences of Parkinson's disease (PD), we sought to infer the progression of PD via the ordering of brain structural alterations from cross-sectional MRI observations. Having measured cortical thinning in gray matter (GM) regions and disintegrity in white matter (WM) regions as MRI markers of structural alterations for 130 patients with PD (69 ± 10 years, 72 men), stochastic simulation based on the probabilistic relationship between the brain regions was conducted to infer the ordering of structural alterations across all brain regions and the staging of structural alterations according to changes in clinical status. The ordering of structural alterations represented WM disintegrity tending to occur earlier than cortical thinning. The staging of structural alterations indicated structural alterations happening mostly before major disease complications such as postural instability and dementia. Later disease states predicted by the sequence of structural alterations were significantly related to more severe clinical symptoms. The relevance of the ordering of brain structural alterations to the severity of clinical symptoms suggests the clinical feasibility of predicting PD progression states.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.