ArticleClinical journal of the American Society of Nephrology : CJASN2022
Urine Output Monitoring for the Diagnosis of Early-Onset Acute Kidney Injury in Very Preterm Infants.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Risk factors for acute kidney injury in very-low birth weight newborns: a systematic review with meta-analysis.European journal of pediatrics · 2024Pooled it
- Incidence and risk factors of vancomycin-associated nephrotoxicity among neonates in the intensive care unit: a retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association between 24-hour urine output during early non-invasive ventilation and short-term adverse outcomes in late preterm infants: a retrospective cohort study.Translational pediatrics · 2026Article
- Perinatal risk factors and 2-year neurodevelopmental outcome of early acute kidney injury in very preterm and very low birth weight infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal acute kidney injury: where are we now?Pediatric nephrology (Berlin, Germany) · 2026Review
- Understanding the Impact of Patent Ductus Arteriosus and Treatment Strategies on Acute Kidney Injury in Preterm Infants.American journal of perinatology · 2026Review
- Neonatal AKI Definition: Is the perfect definition attainable or even desirable? Proceedings from the First International Neonatal Nephrology Symposium.Pediatric research · 2026Article
- Swiss Consensus on Prenatal and Early Postnatal Urinary Tract Dilation: Practical Approach and When to Refer.Children (Basel, Switzerland) · 2024Review
- The Impact of Postoperative Albumin Levels on Furosemide Efficacy in Infants with Congenital Heart Disease.Life (Basel, Switzerland) · 2024Article
- Advocating for the inclusion of kidney health outcomes in neonatal research: best practice recommendations by the Neonatal Kidney Collaborative.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Initial lactate levels linked to oliguria in term neonates with perinatal asphyxia.Pediatric nephrology (Berlin, Germany) · 2024Article
- Low incidence of acute kidney injury in VLBW infants with restrictive use of mechanical ventilation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Incidence, Risk Factors, and Outcomes Associated With Recurrent Neonatal Acute Kidney Injury in the AWAKEN Study.JAMA network open · 2024Article
- Early urine output monitoring in very preterm infants to predict in-hospital neonatal outcomes: a bicentric retrospective cohort study.BMJ open · 2023Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe current threshold used for oliguria in the definition of neonatal AKI has been empirically defined as 1 ml/kg per hour. Urine output criteria are generally poorly documented, resulting in uncertainty in the most accurate threshold to identify AKI in very preterm infants with known tubular immaturity. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a bicentric study including 473 very preterm infants (24
resultsEarly-onset AKI was developed by 101 of 473 (21%) very preterm infants. AKI was diagnosed on the basis of urine output criteria alone (no rise in creatinine) for 27 of 101 (27%) participants. Early-onset AKI was associated with higher risk of death before discharge (adjusted odds ratio, 3.9; 95% confidence interval, 1.9 to 7.8), and the AKI neonatal KDIGO score showed good discriminative performance for neonatal mortality, with an area under the receiver operating characteristic (ROC) curve of 0.68 (95% confidence interval, 0.61 to 0.75). Modified AKI definitions that included higher urine output thresholds showed significantly improved discriminative performance, with areas under the ROC curve of 0.73 (95% confidence interval, 0.66 to 0.80) for the 1.5-ml/kg per hour threshold and 0.75 (95% confidence interval, 0.68 to 0.81) for the 2-ml/kg per hour threshold.
conclusionsEarly-onset AKI was diagnosed on the basis of urine output exclusively for a quarter of the cases. Furthermore, modified AKI definitions that included higher urine output improved the discriminative performance for predicting mortality.
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