ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Sensorimotor Cortex GABA Moderates the Relationship between Physical Exertion and Assessments of Effort.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Increased exertion variability is linked to disruptions in effort assessment in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Environmental uncertainty shapes human effort learning.PLoS biology · 2026Article
- The cognitive and motor determinants of the perception of effort.Cognitive, affective & behavioral neuroscience · 2026Article
- Computational signatures of exertion and rest underlie moment-to-moment dynamics of subjective perceptions of effort and fatigue.Cognitive, affective & behavioral neuroscience · 2026Article
- The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural mechanisms underlying the effects of cognitive fatigue on physical effort-based choice.bioRxiv : the preprint server for biology · 2024Article
- Dopamine facilitates the translation of physical exertion into assessments of effort.NPJ Parkinson's disease · 2023Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Experiences of physical exertion guide our assessments of effort. While these assessments critically influence our decisions to engage in daily activities, little is known about how they are generated. We had female and male human participants exert grip force and assess how effortful these exertions felt; and used magnetic resonance spectroscopy to measure their brain GABA concentration. We found that variability in exertion (i.e., the coefficient of variation in their force exertion profile) was associated with increases in assessments of effort, making participants judge efforts as more costly. GABA levels in the sensorimotor cortex (SM1) moderated the influence of exertion variability on overassessments of effort. In individuals with higher sensorimotor GABA, exertion variability had a diminished influence on overassessments of effort. Essentially, sensorimotor GABA had a protective effect on the influence of exertion variability on inflations of effort assessment. Our findings provide a neurobiological account of how the brain's GABAergic system integrates features of physical exertion into judgments of effort, and how basic sensorimotor properties may influence higher-order judgments of effort.
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Registered trials
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