ArticleJournal of child psychology and psychiatry, and allied disciplines2022
Unique prediction of developmental psychopathology from genetic and familial risk.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
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- Genetic influences on suicide attempt in adolescence: Evaluating mediation by impulsivity and painful and provocative events.JCPP advances · 2026Article
- Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.Molecular psychiatry · 2026Article
- Characterizing the co-occurrence of alcohol experimentation and suicidal thoughts and behaviors in early adolescence.Translational psychiatry · 2026Article
- The impact of collider bias on genetic prediction in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Systematic Review and Meta-Analysis: Phenotypic Correlates of the Autism Polygenic Score.JAACAP open · 2025Article
- Decomposing genetic effects of social connectedness and depression on youth behaviors and long-term clinical outcomes.medRxiv : the preprint server for health sciences · 2025Article
- Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study.Psychological medicine · 2025Article
- Prematurity and genetic liability for autism spectrum disorder.Genome medicine · 2025Article
- Prematurity and Genetic Liability for Autism Spectrum Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Predicting Genetic Risk for Impulsivity and Substance Use in Adolescence.medRxiv : the preprint server for health sciences · 2025Article
- Estimating the total variance explained by whole-brain imaging for zero-inflated outcomes.Communications biology · 2024Article
- Using polygenic scores in combination with symptom rating scales to identify attention-deficit/hyperactivity disorder.BMC psychiatry · 2024Article
- Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores.Translational psychiatry · 2024Article
- Polygenic risk for depression and anterior and posterior hippocampal volume in children and adolescents.Journal of affective disorders · 2024Article
- Polygenic Risk for Schizophrenia, Major Depression, and Post-traumatic Stress Disorder and Hippocampal Subregion Volumes in Middle Childhood.Behavior genetics · 2023Article
- Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.Genome biology · 2023Article
- Editorial: The critical need to assess pubertal development in studies of child and adolescent psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEarly detection is critical for easing the rising burden of psychiatric disorders. However, the specificity of psychopathological measurements and genetic predictors is unclear among youth.
methodsWe measured associations between genetic risk for psychopathology (polygenic risk scores (PRS) and family history (FH) measures) and a wide range of behavioral measures in a large sample (n = 5,204) of early adolescent participants (9-11 years) from the Adolescent Brain and Cognitive Development Study
resultsWhen controlling for genetic risk for other psychiatric disorders, polygenic risk for problematic opioid use (POU) is uniquely associated with lower behavioral inhibition. Attention deficit hyperactivity disorder (ADHD), depression (DEP), and attempted suicide (SUIC) PRS shared many significant associations with externalizing, internalizing, and psychosis-related behaviors. However, when accounting for all measures of genetic and familial risk, these PRS also showed clear, unique patterns of association. Polygenic risk for ASD, BIP, and SCZ, and attempted suicide uniquely predicted variability in cognitive performance. FH accounted for unique variability in behavior above and beyond PRS and vice versa, with FH measures explaining a greater proportion of unique variability compared to the PRS.
conclusionOur results indicate that, among youth, many behaviors show shared genetic influences; however, there is also specificity in the profile of emerging psychopathologies for individuals with high genetic risk for particular disorders. This may be useful for quantifying early, differential risk for psychopathology in development.
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