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ArticleAsian Pacific journal of cancer prevention : APJCP2022

Could Argyrophilic Nucleolar Organizer Regions count mirror DNA Ploidy in Malignant Salivary Gland Tumors?

Marwa T Hussien, Manar Ali Mohamed, Shima Gafar Mansor, Doaa F Temerik, Sherif Farouk Elgayar, Enas Alaa El-Din Abd El-Aziz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marwa T HussienDepartment of Oncologic Pathology, South Egypt Cancer Institute Assiut University, Assiut, Egypt.ORCID 0000-0001-8561-8501
Manar Ali MohamedDepartment of Oral and Maxillofacial Pathology, Faculty of Dentistry, Sphinx University, Assiut, Egypt.
Shima Gafar MansorDepartment of Clinical Pathololgy, South Egypt Cancer Institute Assiut University, Assiut, Egypt.
Doaa F TemerikDepartment of Clinical Pathololgy, South Egypt Cancer Institute Assiut University, Assiut, Egypt.
Sherif Farouk ElgayarDepartment of Oral and Maxillofacial Pathology, Faculty of Dentistry, Minia University, Al Minia, Egypt.
Enas Alaa El-Din Abd El-AzizDepartment of Oral and Maxillofacial Pathology, Faculty of Dentistry, Minia University, Al Minia, Egypt.
Assiut University · EGMinia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNucleolar organizer regions (NORs) are DNA coils that transcribe to ribosomal RNA. The NOR-associated protein, termed argyrophilic NOR (AgNOR), was visible within the nucleus by staining with silver nitrate examination via the light microscope. AgNOR counting is a proliferation marker and may help in the diagnosis and prognosis of various neoplastic lesions. Aneuploidy (abnormal DNA content) can predict the progression, survival and prognosis of the tumors. The aim of this study was to evaluate the role of AgNORs, DNA ploidy status, and total S-phase fraction (TSPF) as prognostic parameters in malignant salivary gland tumors (MSGTs).

methodsThe current study is a retrospective study on a cohort of MSGTs (N=47), to assess AgNORs using Silver Nitrate stain, DNA index (DI), and TSPF using flow cytometry (FCM). Data including tumor size and site, lymphovascular invasion (LVI), lymph node metastasis (LNM) were collected.

resultsThe AgNORs count was statistically significant with MSGT type. DI was found to have a significant association with tumor site, tumor size and MSGT type. In addition, TSPF was found to be significantly associated with LVI. A moderate positive correlation was noted between AgNORs count and TSPF. LNM, tumor site, high AgNORs and low DI were all associated with short disease-free survival (DFS) and poor overall survival (OS).

conclusionThe present study revealed that high AgNORs count, DNA aneuploidy and TSPF had a poor influence on MSGTs prognosis.

Indexed as

Nucleolus Organizer RegionSalivary Gland NeoplasmsAneuploidyHumansLymphatic MetastasisPloidiesRetrospective StudiesSilver NitrateSilver StainingSilver NitrateAgNORsDNA ploidymalignant salivary gland tumorssurvival

Identifiers

PMID35763640
PMCPMC9587811
OpenAlexW4283644903

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