Evidence map›Paper›PMID 35763627›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2022

Investigation of the DNMT3B -579 G>T Promoter Polymorphism in Patients with Colorectal Cancer in an Azerbaijani Population.

Bayram Bayramov, Nuru Bayramov, Hazi Aslanov, Mehraj Abbasov, Shabnam Mammadova, Khagani Eynullazada, Farah Gahramanova, Vugar Yagublu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Association study of the polymorphisms rs2228611 of theMolecular biology research communications · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Bayram BayramovDepartment of Molecular Genetics and Genomics, Genetic Resources Institute of Azerbaijan National Science Academy, Baku, Azerbaijan.ORCID 0000-0002-5176-2174
Nuru BayramovFirst Surgical Disease Department, Azerbaijan Medical University, Baku, Azerbaijan.ORCID 0000-0001-6958-5412
Hazi AslanovDepartment of Surgery, Scientific Center of Surgery, Baku, Azerbaijan.ORCID 0000-0001-6566-4041
Mehraj AbbasovDepartment of Molecular Genetics and Genomics, Genetic Resources Institute of Azerbaijan National Science Academy, Baku, Azerbaijan.ORCID 0000-0002-2564-3411
Shabnam MammadovaFirst Surgical Disease Department, Azerbaijan Medical University, Baku, Azerbaijan.ORCID 0000-0001-8467-0447
Khagani EynullazadaDepartment of Genetics, University of Wisconsin-Madison, Madison, USA.ORCID 0000-0002-0702-9055
Farah GahramanovaFirst Surgical Disease Department, Azerbaijan Medical University, Baku, Azerbaijan.ORCID 0000-0003-4885-0904
Vugar YagubluDepartment of Surgery, Scientific Center of Surgery, Baku, Azerbaijan.
Azerbaijan Medical University · AZUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe main aim of the present study was to determine the clinical significance of the DNA methyltransferase 3B (DNMT3B) gene -579 G>T polymorphism in colorectal cancer (CRC) patients.

methodsA total of 140 patients with CRC and 164 healthy individuals were included in the study. According to the manufacturer's instructions, DNA was isolated from blood, and genotypes were determined on agarose gel by the PCR-RFLP method. Genotype confirmation was performed using Sanger sequencing in randomly selected samples.

resultsWhen comparing the case and control groups, heterozygous GT (OR=0.53; 95% CI=0.32-0.88), under the dominant model (OR=0.53; 95% CI=0.33-0.87), and the mutant T allele (OR=0.71; 95% CI=0.51-0.98) were statistically associated with a reduced risk of CRC. However, when the age, pathological tumor grade and stage, smoking habit, and alcohol consumption were compared, no significant relationship was determined (P>0.05). Furthermore, among males, heterozygous GT was associated with a reduced risk of CRC (OR=0.40; 95% CI=0.19-0.84).

conclusionOur study highlighted that the -579 G>T polymorphism of the DNMT3B gene plays a protective role against CRC development.

Indexed as

Colorectal NeoplasmsGenetic Predisposition to DiseaseAzerbaijanDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BHumansMalePolymorphism, Single NucleotideRisk FactorsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3Bcolorectal cancerDNA MethylationDNMT3BPolymorphism

Identifiers

PMID35763627
PMCPMC9587849
OpenAlexW4283698189

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.