Evidence map›Paper›PMID 35763587›Full record

ArticleInternational journal for numerical methods in biomedical engineering2022

Convection-enhanced delivery with controlled catheter movement: A parametric finite element analysis.

Jason N Mehta, Manuel K Rausch, Christopher G Rylander

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for numerical methods in biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jason N MehtaDepartment of Mechanical Engineering, University of Texas at Austin, Austin, Texas, USA.
Manuel K RauschDepartment of Aerospace Engineering and Engineering Mechanics, University of Texas at Austin, Austin, Texas, USA.
Christopher G RylanderDepartment of Mechanical Engineering, University of Texas at Austin, Austin, Texas, USA.
The University of Texas at Austin · US

Funding

Sub-component for Institution # 16-01848 Novel moleculary targeted therapy of GBMP01CA207206 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEBINSKI, WALDEMAR · 2017 to 2021
$9.0M
Multi-receptor Targeting of GlioblastomaR01CA256285 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Waldemar Debinski · 2021 to 2026
$2.8M
NCI NIH HHS P01 CA207206NCI NIH HHS R01 CA256285
6 · The paper itself

Abstract

Convection-enhanced delivery (CED) is an investigational method for delivering therapeutics directly to the brain for the treatment of glioblastoma. However, it has not become a common clinical therapy due to an inability of CED treatments to deliver therapeutics in a large enough tissue volume to fully saturate the target region. We have recently shown that the combination of controlled catheter movement and constant pressure infusions can be used to significantly increase volume dispersed (V

Indexed as

ConvectionDrug Delivery SystemsBrainCathetersFinite Element Analysisagarose gelbiphasic finite element analysisconstant pressure infusioncontrolled catheter movementconvection-enhanced delivery

Identifiers

PMID35763587
PMCPMC9516958
OpenAlexW4283694680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.