Evidence map›Paper›PMID 35763150›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2022

Beneficial effects of Salvia officinalis essential oil on vanadium-induced testicular injury, DNA damage and histological alterations in Wistar rats.

Fatma Ghorbel Koubaa, Mariem Chaâbane, Nour Chiab, Hajer Jdidi, Mediha Sefi, Ons Boudawara, Mouna Turki, Radhia Gargouri Bouzid, Tahia Boudawara Sellami, Fatma Makni Ayadi and 1 more

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fatma Ghorbel KoubaaLaboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia. fatmaghorbelkoubaa@yahoo.fr.ORCID 0000-0001-7412-4805
Mariem ChaâbaneLaboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia.
Nour ChiabLaboratory of Plant Improvement and Agri-Resources Valorization, National School of Engineers of Sfax (ENIS), Sfax, Tunisia.
Hajer JdidiLaboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia.
Mediha SefiPhysiology and Aquatic Environment Unit, Department of Biological Sciences, University of Tunis El Manar, Tunis, Tunisia.
Ons BoudawaraLaboratory of Histopathology Laboratory, Faculty of Medicine, University of Sfax, Sfax, Tunisia.
Mouna TurkiLaboratory of Biochemistry, Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisia.
Radhia Gargouri BouzidLaboratory of Plant Improvement and Agri-Resources Valorization, National School of Engineers of Sfax (ENIS), Sfax, Tunisia.
Tahia Boudawara SellamiLaboratory of Histopathology Laboratory, Faculty of Medicine, University of Sfax, Sfax, Tunisia.
Fatma Makni AyadiLaboratory of Biochemistry, Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisia.
Abdelfattah El FekiLaboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia.
University of Sfax · TNTunis El Manar University · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vanadium has been shown to catalyze the generation of reactive oxygen species. Since free radical production and lipid peroxidation are potentially important mediators in testicular physiology and pathophysiology, the present study was conducted to elucidate vanadium-induced oxidative damage in rat testis and the ameliorative role of Salvia officinalis essential oil (SEO) against the adverse effects of this heavy metal. Adult male Wistar rats were treated daily during 10 days either with ammonium metavanadate (5 mg/kg bw, intraperitoneally), SEO (15 mg/kg bw, orally) or their combination. A group of rats receiving daily a saline solution served as a negative control. Vanadium treatment induced a significant decrease in body and reproductive organ weights, serum testosterone level and sperm number and motility. An increase in lipid peroxidation and protein oxidation as well as a marked inhibition in the activities of antioxidant enzymes in the testes and seminal vesicles indicated the occurrence of oxidative stress after vanadium toxicity. Histopathological changes in testis and seminal vesicles were also observed following vanadium administration. However, co-administration of SEO to vanadium-treated rats resulted in an appreciable improvement of these parameters, emphasizing the therapeutic effects of SEO. It can be suggested that SEO mitigates vanadium-induced reproductive damage due to its antioxidant capacity. Thus, we can hypothesize that SEO supplementation could protect against vanadium poisoning.

Indexed as

Oils, VolatileSalvia officinalisAnimalsAntioxidantsDNA DamageLipid PeroxidationMaleOxidative StressRatsRats, WistarReactive Oxygen SpeciesSaline SolutionSeedsTestosteroneVanadiumAntioxidantsOils, VolatileReactive Oxygen SpeciesSaline SolutionTestosteroneVanadiumRatsRedox statusReproductive organsSalvia officinalisVanadium

Identifiers

PMID35763150
OpenAlexW4283643735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.