Evidence map›Paper›PMID 35763060›Full record

ArticleClinical neuroradiology2023

CT-like MR-derived Images for the Assessment of Craniosynostosis and other Pathologies of the Pediatric Skull.

Yannik Leonhardt, Sophia Kronthaler, Georg Feuerriegel, Dimitrios C Karampinos, Benedikt J Schwaiger, Daniela Pfeiffer, Marcus R Makowski, Inga K Koerte, Thomas Liebig, Klaus Woertler and 2 more

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Article in Clinical neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yannik LeonhardtDepartment of Radiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany. yannik.leonhardt@tum.de.ORCID http://orcid.org/0000-0003-0028-6654
Sophia KronthalerDepartment of Radiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Georg FeuerriegelDepartment of Radiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Dimitrios C KarampinosDepartment of Radiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Benedikt J SchwaigerDepartment on Neuroradiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
Daniela PfeifferDepartment of Radiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Marcus R MakowskiDepartment of Radiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Inga K KoertePsychiatric Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Thomas LiebigDepartment of Neuroradiology, University Hospital of Munich (LMU), Munich, Germany.
Klaus WoertlerDepartment of Radiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Marc-Matthias SteinbornDepartment of Diagnostic and Interventional Radiology and Pediatric Radiology, München Klinik Schwabing, Munich, Germany.
Alexandra S GersingDepartment of Neuroradiology, University Hospital of Munich (LMU), Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the diagnostic value of CT-like images based on a 3D T1-weighted spoiled gradient echo-based sequence (T1SGRE) for the visualization of the pediatric skull and the identification of pathologies, such as craniosynostosis or fractures.

methodsIn this prospective study, 20 patients with suspected craniosynostosis (mean age 1.26 ± 1.38 years, 10 females) underwent MR imaging including the T1SGRE sequence and 2 more patients were included who presented with skull fractures (0.5 and 6.3 years, both male). Additionally, the skull of all patients was assessed using radiography or CT in combination with ultrasound. Two radiologists, blinded to the clinical information, evaluated the CT-like images. The results were compared to the diagnosis derived from the other imaging modalities and intraoperative findings. Intrarater and interrater agreement was calculated using Cohen's κ.

resultsOf the 22 patients 8 had a metopic, 4 a coronal and 2 a sagittal craniosynostosis and 2 patients showed a complex combination of craniosynostoses. The agreement between the diagnosis based on the T1SGRE and the final diagnosis was substantial (Cohen's κ = 0.92, 95% confidence interval (CI) 0.77-1.00 for radiologist 1 and κ = 0.76, CI 0.51-1.00 for radiologist 2). Of the patients with fractures, one presented with a ping pong fracture and one with a fracture of the temporal bone. Both radiologists could identify the fractures using the T1SGRE.

conclusionThe visualization of the pediatric skull and the assessment of sutures using a CT-like T1SGRE MR-sequence is feasible and comparable to other imaging modalities, and thus may help to reduce radiation exposure in pediatric patients. The technique may also be a promising imaging tool for other pathologies, such as fractures.

Indexed as

CraniosynostosesTomography, X-Ray ComputedChildChild, PreschoolFemaleHumansInfantMagnetic Resonance ImagingMaleProspective StudiesTemporal BoneChildrenCranial bone imagingMagnetic resonance imagingRadiation exposureSkull

Identifiers

PMID35763060
PMCPMC10014729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.