Observational studyRadiology2022
Persistent
Registry-linked trialOpen access · greenAbstract readObservational Study
In one paragraph
Observational study in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02748798 (Developing Optimal Parameters for Hyperpolarized Noble Gas), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developing Optimal Parameters for Hyperpolarized Noble Gas (3He and 129Xe) and Inert Fluorinated Gas Magnetic Resonance Imaging of Lung Disorders
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review.International journal of environmental research and public health · 2024Pooled it
- Longitudinal Assessment of Chest CT Findings and Pulmonary Function after COVID-19 Infection.Radiology · 2023Trial
- Pulmonary Dysfunction after Pediatric COVID-19.Radiology · 2023Trial
- LongitudinalJournal of magnetic resonance imaging : JMRI · 2026Article
- Characterizing chronic obstructive pulmonary disease using quantitative MRI biomarkers.The British journal of radiology · 2026Review
- Impact of COVID-19 on Subsequent Lung Function in Childhood: A Systematized Review.Health science reports · 2026Review
- Evaluation of Resorcinarene Trimer Methanesulfonate Aggregation in the Presence of Inorganic Salts and Biomolecules in Aqueous Solutions Using UV-vis Spectroscopy and Electrophoresis.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Using hyperpolarised xenon-129 magnetic resonance imaging to investigate longitudinal effects of long COVID on pulmonary function.ERJ open research · 2026Article
- Longitudinal functional lung imaging in children with Post-COVID-19 syndrome.Molecular and cellular pediatrics · 2026Article
- Dual-energy CT based low flow rate, low dose CTPA and lung perfusion in the pulmonary diagnosis of post-COVID-19 syndrome.Frontiers in medicine · 2026Article
- COVID-19-associated neurological and psychological manifestations.Nature reviews. Disease primers · 2025Review
- Design and Implementation of a Multi-Center Trial ofJournal of magnetic resonance imaging : JMRI · 2025Article
- Long COVID: lung pathophysiology and its relationship with cognitive dysfunction.Scientific reports · 2025Article
- Long COVID: Lung Pathophysiology and its Relationship with Cognitive Dysfunction.Research square · 2025Article
- Establishing standardized healthy reference distributions and values for multisiteMagnetic resonance in medicine · 2025Article
- MRI Assessment of Lung Water Density in Individuals Previously Infected With COVID-19: A Cross-Sectional Study.Journal of magnetic resonance imaging : JMRI · 2025Article
- Hyperpolarized Xenon-129 MRI: Narrative Review of Clinical Studies, Testing, and Implementation of Advanced Pulmonary In Vivo Imaging and Its Diagnostic Applications.Diagnostics (Basel, Switzerland) · 2025Review
- UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Phase-resolved Functional Lung MRI Reveals Distinct Lung Perfusion Phenotype in Children and Adolescents with Post-COVID-19 Condition.Radiology · 2025Article
- Alveolar membrane and capillary function in COVID-19 convalescents: insights from chest MRI.European radiology · 2024Article
Corrections and comments
- Commented on by
Authors and funding
18 authors at 1 institution in 2 countries.
Alexander M MathesonFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0002-6022-9507
Marrissa J McIntoshFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0003-2678-458X
Harkiran K KoonerFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0003-4040-4977
Justin LeeFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0003-4133-6021
Vedanth DesaigoudarFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0003-1365-8621
Elianna BierFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0002-2313-3450
Bastiaan DriehuysFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0002-1236-4210
Sarah SvenningsenFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0002-6225-1863
Giles E SantyrFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0001-7396-188X
Miranda KirbyFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0003-2951-784X
Mitchell S AlbertFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).
Yurii ShepelytskyiFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0001-5526-7958
Vira GrynkoFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0002-9580-0072
Alexei OuriadovFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).
Mohamed AbdelrazekFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0001-5626-8223
Inderdeep DhaliwalFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0003-1795-3855
J Michael NicholsonFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).
Grace ParragaFrom the Robarts Research Institute (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Medical Biophysics (A.M.M., M.J.M., H.K.K., V.D., G.P.), Department of Physiology and Pharmacology (J.L., G.P.), Department of Physics and Astronomy (A.O.), Department of Medical Imaging (M.A., G.P.), and Division of Respirology, Department of Medicine (I.D., J.M.N., G.P.), Western University, 1151 Richmond St N, London, ON, Canada N6A 5B7; Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC (E.B., B.D.); Division of Respirology, Department of Medicine, McMaster University, Hamilton, Canada (S.S.); Translational Medicine Program, Hospital for Sick Children, Toronto, Canada (G.E.S.); Department of Medical Biophysics, University of Toronto, Toronto, Canada (G.E.S.); Department of Physics, Ryerson University, Toronto, Canada (M.K.); Chemistry Department, Lakehead University, Thunder Bay, Canada (M.S.A., Y.S., V.G.); Thunder Bay Regional Health Research Institute, Thunder Bay, Canada (M.S.A., Y.S., V.G.); and Northern Ontario School of Medicine, Thunder Bay, Canada (M.S.A.).ORCID 0000-0002-5619-4145
Western University · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with post-acute COVID-19 syndrome (PACS), abnormal gas-transfer and pulmonary vascular density have been reported, but such findings have not been related to each other or to symptoms and exercise limitation. The pathophysiologic drivers of PACS in patients previously infected with COVID-19 who were admitted to in-patient treatment in hospital (or ever-hospitalized patients) and never-hospitalized patients are not well understood. PURPOSE: To determine the relationship of persistent symptoms and exercise limitation with xenon 129 ( MATERIALS AND
methodsIn this prospective study, patients with PACS aged 18-80 years with a positive polymerase chain reaction COVID-19 test were recruited from a quaternary-care COVID-19 clinic between April and October 2021. Participants with PACS underwent spirometry, diffusing capacity of the lung for carbon monoxide (DLco),
resultsForty participants were evaluated, including six controls (mean age ± SD, 35 years ± 15, three women) and 34 participants with PACS (mean age, 53 years ± 13, 18 women), of whom 22 were never hospitalized. The
conclusionXenon 129 (
Indexed as
COVID-19AdolescentAdultAgedAged, 80 and overCarbon MonoxideDyspneaFemaleHumansLungMagnetic Resonance ImagingMaleMiddle AgedPost-Acute COVID-19 SyndromeProspective StudiesQuality of LifeCarbon MonoxideXenon-129Xenon Isotopes
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02748798ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.