ArticleMagnetic resonance in medicine2022
Improving in situ acoustic intensity estimates using MR acoustic radiation force imaging in combination with multifrequency MR elastography.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Performance of a through-transmit aberration correction method for transcranial focused ultrasound: Simulation and experimental evaluation.The Journal of the Acoustical Society of America · 2026Article
- MR-ARFI to evaluate intensity variability and enhance targeting of FUS: A brain study in rats.Magnetic resonance in medicine · 2026Article
- Optimization of MR acoustic radiation force imaging (MR-ARFI) for human transcranial focused ultrasound.Magnetic resonance in medicine · 2025Article
- Magnetic Resonance Acoustic Radiation Force Imaging (MR-ARFI).Journal of magnetic resonance imaging : JMRI · 2025Review
- Practical Targeting Errors During Optically Tracked Transcranial Focused Ultrasound Using MR-ARFI and Array- Based Steering.IEEE transactions on bio-medical engineering · 2024Article
- Article
- Device for Multifocal Delivery of Ultrasound Into Deep Brain Regions in Humans.IEEE transactions on bio-medical engineering · 2024Article
- ITRUSST consensus on standardised reporting for transcranial ultrasound stimulation.Brain stimulationReview
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Authors and funding
4 authors.
Funding
Abstract
purposeMagnetic resonance acoustic radiation force imaging (MR-ARFI) enables focal spot localization during nonablative transcranial ultrasound therapies. As the acoustic radiation force is proportional to the applied acoustic intensity, measured MR-ARFI displacements could potentially be used to estimate the acoustic intensity at the target. However, variable brain stiffness is an obstacle. The goal of this study was to develop and assess a method to accurately estimate the acoustic intensity at the focus using MR-ARFI displacements in combination with viscoelastic properties obtained with multifrequency MR elastography (MRE).
methodsPhantoms with a range of viscoelastic properties were fabricated, and MR-ARFI displacements were acquired within each phantom using multiple acoustic intensities. Voigt model parameters were estimated for each phantom based on storage and loss moduli measured using multifrequency MRE, and these were used to predict the relationship between acoustic intensity and measured displacement.
resultsUsing assumed viscoelastic properties, MR-ARFI displacements alone could not accurately estimate acoustic intensity across phantoms. For example, acoustic intensities were underestimated in phantoms stiffer than the assumed stiffness and overestimated in phantoms softer than the assumed stiffness. This error was greatly reduced using individualized viscoelasticity measurements obtained from MRE.
conclusionWe demonstrated that viscoelasticity information from MRE could be used in combination with MR-ARFI displacements to obtain more accurate estimates of acoustic intensity. Additionally, Voigt model viscosity parameters were found to be predictive of the relaxation rate of each phantom's time-varying displacement response, which could be used to optimize patient-specific MR-ARFI pulse sequences.
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