Evidence map›Paper›PMID 35762796›Full record

ArticleAntimicrobial agents and chemotherapy2022

Plasma and Intrapulmonary Concentrations of Tebipenem following Oral Administration of Tebipenem Pivoxil Hydrobromide to Healthy Adult Subjects.

Keith A Rodvold, Mark H Gotfried, Vipul Gupta, Amanda Ek, Praveen Srivastava, Angela Talley, Jon Bruss

Open access · greenAbstract readClinical Trial, Phase I
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. The oral penems and carbapenems.Clinical microbiology reviews · 2025
    Review
  4. Oral β-lactam combinations are effectiveMicrobiology spectrum · 2025
    Article
  5. Article
  6. Beta-lactam combination treatment overcomes rifampicin resistance in Mycobacterium tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  7. Article
  8. Article
  9. Novel Antimicrobial Agents for Gram-Negative Pathogens.Antibiotics (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Keith A RodvoldUniversity of Illinois-Chicago, Chicago, Illinois, USA.ORCID 0000-0002-7200-7346
Mark H GotfriedUniversity of Illinois-Chicago, Chicago, Illinois, USA.
Vipul GuptaSpero Therapeutics, Inc., Cambridge, Massachusetts, USA.ORCID 0000-0002-8093-5126
Amanda EkSpero Therapeutics, Inc., Cambridge, Massachusetts, USA.
Praveen SrivastavaSpero Therapeutics, Inc., Cambridge, Massachusetts, USA.
Angela TalleySpero Therapeutics, Inc., Cambridge, Massachusetts, USA.
Jon BrussSpero Therapeutics, Inc., Cambridge, Massachusetts, USA.
Spero Therapeutics (United States) · USUniversity of Illinois Chicago · US

Funding

DHHS Office of the Secretary, BARDA HHSO100201800015C
6 · The paper itself

Abstract

Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is an oral carbapenem prodrug being developed for the treatment of serious bacterial infections. The active moiety, tebipenem, has broad-spectrum activity against common

Indexed as

Anti-Bacterial AgentsCOVID-19Administration, OralAdultBronchoalveolar Lavage FluidCarbapenemsHumansLungMonobactamsAnti-Bacterial AgentsCarbapenemsMonobactamstebipenemalveolar macrophagesepithelial lining fluidpharmacokineticsSPR859SPR994tebipenem

Identifiers

PMID35762796
PMCPMC9295559
OpenAlexW4283658128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.