Evidence map›Paper›PMID 35762760›Full record

ArticleJournal of virology2022

The Capsid Precursor Protein of Astrovirus VA1 Is Proteolytically Processed Intracellularly.

Catalina Aguilera-Flores, Tomás López, Fernando Zamudio, Carlos Sandoval-Jaime, Edmundo I Pérez, Susana López, Rebecca DuBois, Carlos F Arias

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  7. Article
  8. Neonatal Fc receptor is a functional receptor for classical human astrovirus.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Structure of the divergent human astrovirus MLB capsid spike.Structure (London, England : 1993) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Catalina Aguilera-FloresDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Tomás LópezDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Fernando ZamudioDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Carlos Sandoval-JaimeDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Edmundo I PérezDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, USA.
Susana LópezDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Rebecca DuBoisDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, USA.ORCID 0000-0003-4185-5673
Carlos F AriasDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.ORCID 0000-0003-3130-4501
Universidad Nacional Autónoma de México · MXUniversity of California, Santa Cruz · US

Funding

Structural, mechanistic, and antigenic insights into the human astrovirus capsidR01AI144090 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI DUBOIS, REBECCA MICHELLE · 2019 to 2023
$2.2M
NIAID NIH HHS R01 AI144090
6 · The paper itself

Abstract

Human astrovirus VA1 has been associated with neurological disease in immunocompromised patients, and its recent propagation in cell culture has opened the possibility to study its biology. Unlike classical human astroviruses, VA1 growth was found to be independent of trypsin during virus replication

Indexed as

Astroviridae InfectionsCapsid ProteinsMamastrovirusProtein PrecursorsCaco-2 CellsCapsidHumansIntracellular SpaceTrypsinCapsid ProteinsProtein PrecursorsTrypsincapsid processingplus-strand RNA virusproteolytical cleavageRNA virusVA1 astrovirus

Identifiers

PMID35762760
PMCPMC9327696
OpenAlexW4283656137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.