Evidence map›Paper›PMID 35762633›Full record

ArticleDrug delivery2022

Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid.

Aixa Aguilera-Garrido, Elena Arranz, María José Gálvez-Ruiz, Juan Antonio Marchal, Francisco Galisteo-González, Linda Giblin

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Role of maslinic acid in ischemia-reperfusion-induced testicular injury in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. A Patent Analysis on Nano Drug Delivery Systems.Recent patents on nanotechnology · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Aixa Aguilera-GarridoDepartment of Applied Physics, University of Granada, Granada, Spain.ORCID 0000-0003-3470-7904
Elena ArranzTeagasc Food Research Centre, Moorepark, Fermoy, Ireland.ORCID 0000-0002-8833-9257
María José Gálvez-RuizDepartment of Applied Physics, University of Granada, Granada, Spain.ORCID 0000-0003-0080-7827
Juan Antonio MarchalExcellence Research Unit "Modeling Nature" (MNat), University of Granada, Granada, Spain.ORCID 0000-0002-4996-8261
Francisco Galisteo-GonzálezDepartment of Applied Physics, University of Granada, Granada, Spain.ORCID 0000-0001-8941-5752
Linda GiblinTeagasc Food Research Centre, Moorepark, Fermoy, Ireland.ORCID 0000-0002-9354-3121
Universidad de Granada · ESTeagasc - The Irish Agriculture and Food Development Authority · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maslinic acid (MA) is a plant-derived, low water-soluble compound with antitumor activity. We have formulated MA in the form of solid lipid nanoparticles (SLNs) with three different shell compositions: Poloxamer 407 (PMA), dicarboxylic acid-Poloxamer 407 (PCMA), and HA-coated PCMA (PCMA-HA). These SLNs improved the solubility of MA up to 7.5 mg/mL, are stable in a wide range of pH, and increase the bioaccessibility of MA after

Indexed as

LipidsPoloxamerTriterpenesAdministration, OralCaco-2 CellsHumansLiposomesNanoparticlesOleanolic AcidPermeabilityLipid NanoparticlesLipidsLiposomesmaslinic acidOleanolic AcidPoloxamerTriterpenesbioaccessibilitydigestionintestinal permeabilitymaslinic acidSolid lipid nanoparticle

Identifiers

PMID35762633
PMCPMC9246121
OpenAlexW4283694272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.