Evidence map›Paper›PMID 35762582›Full record

ArticleeLife2022

Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context.

Atanas Radkov, Anne L Sapiro, Sebastian Flores, Corey Henderson, Hayden Saunders, Rachel Kim, Steven Massa, Samuel Thompson, Chase Mateusiak, Jacob Biboy and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Two cysteines control Tse1 secretion by H1-T6SS in Pseudomonas aeruginosa.Protein science : a publication of the Protein Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 12 institutions in 5 countries.

Atanas RadkovDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0001-7418-279X
Anne L SapiroDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-6612-8272
Sebastian FloresUniversity of Miami, Miami, United States.
Corey HendersonInBios International, Seattle, United States.
Hayden SaundersDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-7582-3031
Rachel KimPacific Northwest University of Health Sciences, Yakima, United States.ORCID 0000-0003-3793-4264
Steven MassaDepartment of Biology, Stanford University, Stanford, United States.
Samuel ThompsonDepartment of Bioengineering, Stanford University, Stanford, United States.
Chase MateusiakComputer Science Department, Washington University in St. Louis, St. Louis, United States.ORCID 0000-0002-2890-4242
Jacob BiboyCentre for Bacterial Cell Biology, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0002-1286-6851
Ziyi ZhaoDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
Lea M StaritaDepartment of Genome Sciences, University of Washington, Seattle, United States.
William L HatlebergIndependent Researcher, Pittsburg, United States.ORCID 0000-0002-0423-7123
Waldemar VollmerCentre for Bacterial Cell Biology, Newcastle University, Newcastle upon Tyne, United Kingdom.
Alistair B RussellDivision of Biological Sciences, University of California, San Diego, La Jolla, United States.
Jean-Pierre SimorreUniversité Grenoble Alpes, Grenoble, France.ORCID 0000-0002-7943-1342
Spencer Anthony-CahillChemistry Department, Western Washington University, Bellingham, United States.
Peter BrzovicDepartment of Biochemistry, University of Washington, Seattle, United States.
Beth HayesDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0001-6633-751X
Seemay ChouDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-7271-303X
University of California, San Francisco · USUniversity of Newcastle Australia · AUUniversity of Washington · USBioengineering Center · RUInBios International (United States) · USInstitut des langues et cultures d'Europe, Amérique, Afrique, Asie et Australie · FRPacific Northwest University of Health Sciences · USStanford University · USUniversity of California San Diego · USUniversity of Miami · USWashington University in St. Louis · USWestern Washington University · US

Funding

Control of bacterial infections by a horizontally acquired host peptidoglycan amidaseR01AI132851 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PANNING, BARBARA · 2019 to 2022
$1.6M
NIAID NIH HHS R01 AI132851
6 · The paper itself

Abstract

Members of the bacterial

Indexed as

AmidohydrolasesPeptidoglycanAnti-Bacterial AgentsBacterial ProteinsCell WallPseudomonas aeruginosaAmidohydrolasesAnti-Bacterial AgentsBacterial ProteinsPeptidoglycanbiochemistrychemical biologycognate immunitydeep mutational scanningE. colihost–microbe interactioninfectious diseasemicrobiologypeptidoglycantopologytype VI amidase effector

Identifiers

PMID35762582
PMCPMC9270033
OpenAlexW4283698895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.