ArticleeLife2022
Aberrant cortical development is driven by impaired cell cycle and translational control in a
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
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Who cites it
42 citing papers in PubMed, 55 citations in OpenAlex.
- Sex-linked helicases DDX3X and DDX3Y regulate G-quadruplex-associated stress in neurons.Cell death & disease · 2026Article
- Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity.Translational psychiatry · 2026Article
- Cell type-dependent suppression of the RNA helicase DDX3Y levels by the close paralog DDX3X.Frontiers in cell and developmental biology · 2026Article
- Impaired cortical development and translational control in a missense mouse model of DDX3X syndrome.Disease models & mechanisms · 2025Article
- Exploration of a DDX3X Gene Supplementation Therapy Including Expanded Characterization and Novel Findings of Sleep Disturbances inBiological psychiatry global open science · 2025Article
- Regulatory role of the N-terminal intrinsically disordered region of the DEAD-box RNA helicase DDX3X in selective RNA recognition.Nature communications · 2025Article
- Article
- An iPSC-based model of 47,XYY Jacobs syndrome reveals a DNA methylation-independent transcriptional dysregulation shared with male X aneuploid cells.Genome research · 2025Article
- Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X.Nature communications · 2025Article
- DEAD/DEAH-box RNA helicases shape the risk of neurodevelopmental disorders.Trends in genetics : TIG · 2025Review
- Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders.Cell systems · 2025Article
- Diverse mechanisms of DDX3Y suppression by DDX3X.bioRxiv : the preprint server for biology · 2025Article
- Differential neurogenic patterns underlie the formation of primary and secondary areas in the developing somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis.PLoS biology · 2025Article
- Post-transcriptional cross- and auto-regulation buffer expression of the human RNA helicasesGenome research · 2025Article
- A subpopulation of cortical neurons altered by mutations in the autism risk gene DDX3X.Biology open · 2025Article
- Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations.PLoS genetics · 2025Article
- O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control.Open biology · 2025Article
- Deficiency ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Emerging X-linked genes associated with neurodevelopmental disorders in females.Current opinion in neurobiology · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Mariah L HoyeDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.ORCID 0000-0002-3430-2782
Lorenzo CalvielloCentre for Functional Genomics, Human Technopole, Milan, Italy.
Abigail J PoffDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.ORCID 0000-0001-6267-4201
Nna-Emeka EjimoguDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Carly R NewmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Maya D MontgomeryDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.
Jianhong OuDepartment of Cell Biology, Duke University Medical Center, Durham, United States.
Stephen N FloorDepartment of Cell and Tissue Biology, UCSF, San Francisco, United States.ORCID 0000-0002-9965-9694
Debra L SilverDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.ORCID 0000-0001-9189-844X
Duke University · USCell and Tissue Systems (United States) · USHuman Technopole · IT
Funding
U-RISE at University of Maryland Baltimore CountyT34GM136497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PHYLLIS R ROBINSON · 2020 to 2026
$9.5MTraining Program in Developmental & Stem Cell BiologyT32HD040372 · NICHD · DUKE UNIVERSITY · PI Terry H Lechler · 2001 to 2026
$8.9MMechanisms of neural progenitor division in the developing brainR01NS083897 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2013 to 2023
$3.4MInvestigating sex differences in DDX3X mouse modelsR01NS120667 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA L. · 2021 to 2025
$3.4MThe impact of human RNA diversity on protein production and cell fateDP2GM132932 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLOOR, STEPHEN NICHOLAS · 2018 to 2018
$2.4MDistal mRNA localization and translation in neural stem cells of the developing brainR01NS110388 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2018 to 2022
$1.8MCell biological and proteomic investigation of pathogenic DDX3X missense mutations during neurogenesisR21HD104514 · NICHD · DUKE UNIVERSITY · PI SILVER, DEBRA · 2021 to 2022
$443kThe Role of an Intellectual Disability Gene, DDX3X, In Neural Progenitors During Brain DevelopmentF32NS112566 · NINDS · DUKE UNIVERSITY · PI HOYE, MARIAH LAWLER · 2019 to 2022
$196kNICHD NIH HHS R21 HD104514NICHD NIH HHS T32 HD040372NIGMS NIH HHS DP2 GM132932NIGMS NIH HHS T34 GM136497NINDS NIH HHS F32 NS112566NINDS NIH HHS R01 NS083897NINDS NIH HHS R01 NS110388NINDS NIH HHS R01 NS120667
Abstract
Mutations in the RNA helicase,
Indexed as
DEAD-box RNA HelicasesMicrocephalyNeurogenesisAnimalsCell CycleCell DivisionFemaleLoss of Function MutationMaleMiceMinor Histocompatibility AntigensSyndromeDdx3x protein, mouseDEAD-box RNA HelicasesMinor Histocompatibility Antigenscortical developmentDDX3X syndromedevelopmental biologymouseneurogenesisneuroscienceradial gliaRNA helicasetranslation
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.