Evidence map›Paper›PMID 35762456›Full record

ArticleCancer medicine2022

Oncolytic adenovirus H101 ameliorate the efficacy of anti-PD-1 monotherapy in colorectal cancer.

Lili Huang, Huaxin Zhao, Mengying Shan, Hong Chen, Bin Xu, Yang He, Yu Zhao, Zhuqing Liu, Jianhua Chen, Qing Xu

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lili HuangDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Huaxin ZhaoDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Mengying ShanAnhui Medical University, HeFei, China.
Hong ChenDepartment of Gastrointestinal Surgery, Fujian Provincial Hospital, Fuzhou, China.
Bin XuDepartment of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shangai, China.
Yang HeDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Yu ZhaoDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Zhuqing LiuDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-3852-8807
Jianhua ChenDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-6543-991X
Qing XuDepartment of Oncology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Tongji University · CNAnhui Medical University · CNFujian Provincial Hospital · CN

Funding

National Natural Science Foundation of China 81803090National Natural Science Foundation of China 81902896National Natural Science Foundation of China 82172735Pujiang Fostering Program of Shanghai Tenth Peoples Hospital 040118024Pujiang Fostering Program of Shanghai Tenth Peoples Hospital 2021SYPDRC016Shanghai Pujiang Program 21PJD055Shanghai Sailing Program 19YF1438300Shanghai Science and Technology Committee 18DZ1910102Western Medicine Guiding Project of Shanghai Science and Technology Commission 17411967300
6 · The paper itself

Abstract

backgroundImmune checkpoint blockade therapy with anti-programmed cell death (PD)-1 antibodies provides therapeutic effect for many patients of various cancers but remains inadequate in colorectal cancer (CRC) patients. The present study aims to assess the efficacy of oncolytic adenovirus (Onco

methodsThe estimating relative subsets of RNA transcripts algorithm was used for estimating the infiltrated immune cells in melanoma and CRC tissues. The efficacy of Onco

resultsThe Cancer Genome Atlas database indicated that CD8

conclusionThe present study elucidates that Onco

Indexed as

Colorectal NeoplasmsMelanomaAdenoviridaeAnimalsCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalImmunotherapyMiceanti-PD-1 therapyCD8+ T cellscolorectal cancerimmunotherapyoncolytic adenovirus

Identifiers

PMID35762456
PMCPMC9741988
OpenAlexW4283657053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.