ArticleHypertension (Dallas, Tex. : 1979)2022
Association of Blood Pressure-Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth.
Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Precision approaches to paediatric hypertension: linking pathophysiology to therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Prehypertension in young physically active adults: early vascular alterations and implications for exercise-intensity prescription.Frontiers in cardiovascular medicine · 2026Article
- Hypertension and vascular health in the young.Current opinion in pediatrics · 2025Review
- Cardiovascular Assessments in Children and Adolescents With Hypertension.Reviews in cardiovascular medicine · 2025Review
- Youth Blood Pressure and Target Organ Injury Markers: The SHIP AHOY Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Central arterial stiffness in young adults with perinatal HIV exposure and infection.AIDS (London, England) · 2025Article
- Pediatric Blood Pressure and Cardiovascular Health in Adulthood.Current hypertension reports · 2024Review
- Association of pulse pressure and aortic root diameter in elderly Chinese patients with chronic heart failure.Frontiers in cardiovascular medicine · 2024Article
- Secular trends and age-specific distribution of blood pressure in Japanese adolescents aged 12-18 years in 2000-2019.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Body Mass Index (BMI) Is the Strongest Predictor of Systemic Hypertension and Cardiac Mass in a Cohort of Children.Nutrients · 2023Article
- Pediatric blood pressure category predicts longitudinal blood pressure change in adolescence and early adulthood.Pediatric research · 2023Article
- Vascular function in hypertension: does gender dimension matter?Journal of human hypertension · 2023Review
- Blood Pressure in Children in the 21st Century: What Do We Know and Where Do We Go From Here?Hypertension (Dallas, Tex. : 1979) · 2023Review
- Can Surrogate Markers Help Define Cardiovascular Disease in Youth?Current atherosclerosis reports · 2023Review
- Association of Area Deprivation With Primary Hypertension Diagnosis Among Youth Medicaid Recipients in Delaware.JAMA network open · 2023Article
- The enigma of primary hypertension in childhood.Frontiers in cardiovascular medicine · 2022Review
- Arterial stiffness is associated with prehypertension in both non-hypertensives and treated hypertensives-A matched case control study.Indian heart journalArticle
Corrections and comments
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Authors and funding
19 authors at 14 institutions in 3 countries.
Funding
Abstract
backgroundHypertension-related increased arterial stiffness predicts development of target organ damage (TOD) and cardiovascular disease. We hypothesized that blood pressure (BP)-related increased arterial stiffness is present in youth with elevated BP and is associated with TOD.
methodsParticipants were stratified by systolic BP into low- (systolic BP <75th percentile, n=155), mid- (systolic BP ≥80th and <90th percentile, n=88), and high-risk BP categories (≥90th percentile, n=139), based on age-, sex- and height-specific pediatric BP cut points. Clinic BP, 24-hour ambulatory BP monitoring, anthropometrics, and laboratory data were obtained. Arterial stiffness measures included carotid-femoral pulse wave velocity and aortic stiffness. Left ventricular mass index, left ventricular systolic and diastolic function, and urine albumin/creatinine were collected. ANOVA with Bonferroni correction was used to evaluate differences in cardiovascular risk factors, pulse wave velocity, and cardiac function across groups. General linear models were used to examine factors associated with arterial stiffness and to determine whether arterial stiffness is associated with TOD after accounting for BP.
resultsPulse wave velocity increased across groups. Aortic distensibility, distensibility coefficient, and compliance were greater in low than in the mid or high group. Significant determinants of arterial stiffness were sex, age, adiposity, BP, and LDL (low-density lipoprotein) cholesterol. Pulse wave velocity and aortic compliance were significantly associated with TOD (systolic and diastolic cardiac function and urine albumin/creatinine ratio) after controlling for BP.
conclusionsHigher arterial stiffness is associated with elevated BP and TOD in youth emphasizing the need for primary prevention of cardiovascular disease.
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Registered trials
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